tetano
Editor, Senior Moderator
Elife
. 2023 Jul 18;12:e84753.
doi: 10.7554/eLife.84753. Online ahead of print. Association of close-range contact patterns with SARS-CoV-2: a household transmission study
Jackie Kleynhans[SUP] 1 [/SUP], Lorenzo Dall'Amico[SUP] 2 [/SUP], Laetitia Gauvin[SUP] 2 [/SUP], Michele Tizzoni[SUP] 2 [/SUP], Lucia Maloma[SUP] 3 [/SUP], Sibongile Walaza[SUP] 1 [/SUP], Neil A Martinson[SUP] 3 [/SUP], Anne von Gottberg[SUP] 1 [/SUP], Nicole Wolter[SUP] 1 [/SUP], Mvuyo Makhasi[SUP] 1 [/SUP], Cheryl Cohen[SUP] 1 [/SUP], Ciro Cattuto[SUP] 4 [/SUP], Stefano Tempia[SUP] 1 [/SUP]; SA‐S‐HTS Group
Collaborators, Affiliations
Background: Households are an important location for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission, especially during periods where travel and work was restricted to essential services. We aimed to assess the association of close-range contact patterns with SARS-CoV-2 transmission.
Methods: We deployed proximity sensors for two weeks to measure face-to-face interactions between household members after SARS-CoV-2 was identified in the household, in South Africa, 2020 - 2021. We calculated duration, frequency and average duration of close range proximity events with SARS-CoV-2 index cases. We assessed the association of contact parameters with SARS-CoV-2 transmission using mixed effects logistic regression accounting for index and household member characteristics.
Results: We included 340 individuals (88 SARS-CoV-2 index cases and 252 household members). On multivariable analysis, factors associated with SARS-CoV-2 acquisition were index cases with minimum C[SUB]t[/SUB] value <30 (aOR 10.6 95%CI 1.4-80.1) vs >35, and female contacts (aOR 2.4 95%CI 1.2-4.8). No contact parameters were associated with acquisition (aOR 1.0-1.1) for any of the duration, frequency, cumulative time in contact or average duration parameters.
Conclusion: We did not find an association between close-range proximity events and SARS-CoV-2 household transmission. Our findings may be due to study limitations, that droplet-mediated transmission during close-proximity contacts play a smaller role than airborne transmission of SARS-CoV-2 in the household, or due to high contact rates in households.
Funding: Wellcome Trust (Grant number 221003/Z/20/Z) in collaboration with the Foreign, Commonwealth and Development Office, United Kingdom.
Keywords: epidemiology; global health; infectious disease; microbiology; viruses.
. 2023 Jul 18;12:e84753.
doi: 10.7554/eLife.84753. Online ahead of print. Association of close-range contact patterns with SARS-CoV-2: a household transmission study
Jackie Kleynhans[SUP] 1 [/SUP], Lorenzo Dall'Amico[SUP] 2 [/SUP], Laetitia Gauvin[SUP] 2 [/SUP], Michele Tizzoni[SUP] 2 [/SUP], Lucia Maloma[SUP] 3 [/SUP], Sibongile Walaza[SUP] 1 [/SUP], Neil A Martinson[SUP] 3 [/SUP], Anne von Gottberg[SUP] 1 [/SUP], Nicole Wolter[SUP] 1 [/SUP], Mvuyo Makhasi[SUP] 1 [/SUP], Cheryl Cohen[SUP] 1 [/SUP], Ciro Cattuto[SUP] 4 [/SUP], Stefano Tempia[SUP] 1 [/SUP]; SA‐S‐HTS Group
Collaborators, Affiliations
- PMID: 37461328
- DOI: 10.7554/eLife.84753
Background: Households are an important location for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission, especially during periods where travel and work was restricted to essential services. We aimed to assess the association of close-range contact patterns with SARS-CoV-2 transmission.
Methods: We deployed proximity sensors for two weeks to measure face-to-face interactions between household members after SARS-CoV-2 was identified in the household, in South Africa, 2020 - 2021. We calculated duration, frequency and average duration of close range proximity events with SARS-CoV-2 index cases. We assessed the association of contact parameters with SARS-CoV-2 transmission using mixed effects logistic regression accounting for index and household member characteristics.
Results: We included 340 individuals (88 SARS-CoV-2 index cases and 252 household members). On multivariable analysis, factors associated with SARS-CoV-2 acquisition were index cases with minimum C[SUB]t[/SUB] value <30 (aOR 10.6 95%CI 1.4-80.1) vs >35, and female contacts (aOR 2.4 95%CI 1.2-4.8). No contact parameters were associated with acquisition (aOR 1.0-1.1) for any of the duration, frequency, cumulative time in contact or average duration parameters.
Conclusion: We did not find an association between close-range proximity events and SARS-CoV-2 household transmission. Our findings may be due to study limitations, that droplet-mediated transmission during close-proximity contacts play a smaller role than airborne transmission of SARS-CoV-2 in the household, or due to high contact rates in households.
Funding: Wellcome Trust (Grant number 221003/Z/20/Z) in collaboration with the Foreign, Commonwealth and Development Office, United Kingdom.
Keywords: epidemiology; global health; infectious disease; microbiology; viruses.