tetano
Editor, Senior Moderator
Emerg Infect Dis
. 2023 Feb;29(2):381-388.
doi: 10.3201/eid2902.221422.
Correlates of Protection, Thresholds of Protection, and Immunobridging among Persons with SARS-CoV-2 Infection
David S Khoury, Timothy E Schlub, Deborah Cromer, Megan Steain, Youyi Fong, Peter B Gilbert, Kanta Subbarao, James A Triccas, Stephen J Kent, Miles P Davenport
Abstract
Several studies have shown that neutralizing antibody levels correlate with immune protection from COVID-19 and have estimated the relationship between neutralizing antibodies and protection. However, results of these studies vary in terms of estimates of the level of neutralizing antibodies required for protection. By normalizing antibody titers, we found that study results converge on a consistent relationship between antibody levels and protection from COVID-19. This finding can be useful for planning future vaccine use, determining population immunity, and reducing the global effects of the COVID-19 pandemic.
Keywords: 2019 novel coronavirus disease; COVID-19; SARS-CoV-2; coronavirus disease; correlates of protection; neutralizing antibody; respiratory infections; severe acute respiratory syndrome coronavirus 2; standardization; vaccine efficacy; viruses; zoonoses.
. 2023 Feb;29(2):381-388.
doi: 10.3201/eid2902.221422.
Correlates of Protection, Thresholds of Protection, and Immunobridging among Persons with SARS-CoV-2 Infection
David S Khoury, Timothy E Schlub, Deborah Cromer, Megan Steain, Youyi Fong, Peter B Gilbert, Kanta Subbarao, James A Triccas, Stephen J Kent, Miles P Davenport
- PMID: 36692375
- DOI: 10.3201/eid2902.221422
Abstract
Several studies have shown that neutralizing antibody levels correlate with immune protection from COVID-19 and have estimated the relationship between neutralizing antibodies and protection. However, results of these studies vary in terms of estimates of the level of neutralizing antibodies required for protection. By normalizing antibody titers, we found that study results converge on a consistent relationship between antibody levels and protection from COVID-19. This finding can be useful for planning future vaccine use, determining population immunity, and reducing the global effects of the COVID-19 pandemic.
Keywords: 2019 novel coronavirus disease; COVID-19; SARS-CoV-2; coronavirus disease; correlates of protection; neutralizing antibody; respiratory infections; severe acute respiratory syndrome coronavirus 2; standardization; vaccine efficacy; viruses; zoonoses.