tetano
Editor, Senior Moderator
Emerg Infect Dis
. 2021 Jun 23;27(9).
doi: 10.3201/eid2709.211159. Online ahead of print.
Genomic Evolution of SARS-CoV-2 Virus in Immunocompromised Patient, Ireland
Maureen Lynch, Guerrino Macori, Séamus Fanning, Edel O'Regan, Eoin Hunt, Dermot O'Callaghan, Brian McCullagh, Cormac Jennings, Anne Fortune
Abstract
We examined virus genomic evolution in an immunocompromised patient with prolonged severe acute respiratory syndrome coronavirus 2 infection. Genomic sequencing revealed genetic variation during infection: 3 intrahost mutations and possible superinfection with a second strain of the virus. Prolonged infection in immunocompromised patients may lead to emergence of new virus variants.
Keywords: 2019 novel coronavirus disease; B-cell therapy; COVID-19; SARS-CoV-2; coronavirus disease; immunocompromised; respiratory infections; severe acute respiratory syndrome coronavirus 2; superinfection; virus evolution; viruses; zoonoses.
. 2021 Jun 23;27(9).
doi: 10.3201/eid2709.211159. Online ahead of print.
Genomic Evolution of SARS-CoV-2 Virus in Immunocompromised Patient, Ireland
Maureen Lynch, Guerrino Macori, Séamus Fanning, Edel O'Regan, Eoin Hunt, Dermot O'Callaghan, Brian McCullagh, Cormac Jennings, Anne Fortune
- PMID: 34161223
- DOI: 10.3201/eid2709.211159
Abstract
We examined virus genomic evolution in an immunocompromised patient with prolonged severe acute respiratory syndrome coronavirus 2 infection. Genomic sequencing revealed genetic variation during infection: 3 intrahost mutations and possible superinfection with a second strain of the virus. Prolonged infection in immunocompromised patients may lead to emergence of new virus variants.
Keywords: 2019 novel coronavirus disease; B-cell therapy; COVID-19; SARS-CoV-2; coronavirus disease; immunocompromised; respiratory infections; severe acute respiratory syndrome coronavirus 2; superinfection; virus evolution; viruses; zoonoses.