tetano
Editor, Senior Moderator
Emerg Infect Dis
. 2020 May 21;26(9).
doi: 10.3201/eid2609.202095. Online ahead of print.
Pathology and Pathogenesis of SARS-CoV-2 Associated With Fatal Coronavirus Disease, United States
Roosecelis B Martines, Jana M Ritter, Eduard Matkovic, Joy Gary, Brigid C Bollweg, Hannah Bullock, Cynthia S Goldsmith, Luciana Silva-Flannery, Josilene N Seixas, Sarah Reagan-Steiner, Timothy Uyeki, Amy Denison, Julu Bhatnagar, Wun-Ju Shieh, Sherif R Zaki, COVID-19 Pathology Working Group
Abstract
An ongoing pandemic of coronavirus disease (COVID-19) is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Characterization of the histopathology and cellular localization of SARS-CoV-2 in the tissues of patients with fatal COVID-19 is critical to further understand its pathogenesis and transmission and for public health prevention measures. We report clinicopathologic, immunohistochemical, and electron microscopic findings in tissues from 8 fatal laboratory-confirmed cases of SARS-CoV-2 infection in the United States. All cases except 1 were in residents of long-term care facilities. In these patients, SARS-CoV-2 infected epithelium of the upper and lower airways with diffuse alveolar damage as the predominant pulmonary pathology. SARS-CoV-2 was detectable by immunohistochemistry and electron microscopy in conducting airways, pneumocytes, alveolar macrophages, and a hilar lymph node but was not identified in other extrapulmonary tissues. Respiratory viral co-infections were identified in 3 cases; 3 cases had evidence of bacterial co-infection.
Keywords: 2019 novel coronavirus disease; COVID-19; SARS-CoV-2; coronavirus; coronavirus disease; diffuse alveolar damage; electron microscopy; histopathology; immunohistochemistry; pathology; respiratory infections; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses.
. 2020 May 21;26(9).
doi: 10.3201/eid2609.202095. Online ahead of print.
Pathology and Pathogenesis of SARS-CoV-2 Associated With Fatal Coronavirus Disease, United States
Roosecelis B Martines, Jana M Ritter, Eduard Matkovic, Joy Gary, Brigid C Bollweg, Hannah Bullock, Cynthia S Goldsmith, Luciana Silva-Flannery, Josilene N Seixas, Sarah Reagan-Steiner, Timothy Uyeki, Amy Denison, Julu Bhatnagar, Wun-Ju Shieh, Sherif R Zaki, COVID-19 Pathology Working Group
- PMID: 32437316
- DOI: 10.3201/eid2609.202095
Abstract
An ongoing pandemic of coronavirus disease (COVID-19) is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Characterization of the histopathology and cellular localization of SARS-CoV-2 in the tissues of patients with fatal COVID-19 is critical to further understand its pathogenesis and transmission and for public health prevention measures. We report clinicopathologic, immunohistochemical, and electron microscopic findings in tissues from 8 fatal laboratory-confirmed cases of SARS-CoV-2 infection in the United States. All cases except 1 were in residents of long-term care facilities. In these patients, SARS-CoV-2 infected epithelium of the upper and lower airways with diffuse alveolar damage as the predominant pulmonary pathology. SARS-CoV-2 was detectable by immunohistochemistry and electron microscopy in conducting airways, pneumocytes, alveolar macrophages, and a hilar lymph node but was not identified in other extrapulmonary tissues. Respiratory viral co-infections were identified in 3 cases; 3 cases had evidence of bacterial co-infection.
Keywords: 2019 novel coronavirus disease; COVID-19; SARS-CoV-2; coronavirus; coronavirus disease; diffuse alveolar damage; electron microscopy; histopathology; immunohistochemistry; pathology; respiratory infections; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses.