tetano
Editor, Senior Moderator
Environ Res
. 2020 Oct 15;110317.
doi: 10.1016/j.envres.2020.110317. Online ahead of print.
Assessing the consequences of environmental exposures on the expression of the human receptor and proteases involved in SARS-CoV-2 cell-entry
Manon Watzky[SUP] 1 [/SUP], Maud de Dieuleveult[SUP] 1 [/SUP], Anne Letessier[SUP] 1 [/SUP], Claude Saint-Ruf[SUP] 1 [/SUP], Benoit Miotto[SUP] 2 [/SUP]
Affiliations
Abstract
The role of environmental condition on the infection by the novel pathogenic SARS-CoV-2 virus remains uncertain. In here, exploiting a large panel of publicly available genome-wide data, we investigated whether the human receptor ACE2 and human proteases TMPRSS2, FURIN and CATHEPSINs (B, L and V), which are involved in SARS-CoV-2 cell entry, are transcriptionally regulated by environmental cues. We report that more than 50 chemicals modulate the expression of ACE2 or human proteases important for SARS-CoV-2 cell entry. We further demonstrate that transcription factor AhR, which is commonly activated by pollutants, binds to the promoter of TMPRSS2 and enhancers and/or promoters of Cathepsin B, L and V encoding genes. Our exploratory study documents an influence of environmental exposures on the expression of genes involved in SARS-CoV-2 cell entry. These results could be conceptually and medically relevant to our understanding of the COVID-19 disease, and should be further explored in laboratory and epidemiologic studies.
Keywords: ACE2; COVID-19; Cathepsin genes; Coronavirus; Environmental exposure; FURIN; SARS-CoV-2; TMPRSS2.
. 2020 Oct 15;110317.
doi: 10.1016/j.envres.2020.110317. Online ahead of print.
Assessing the consequences of environmental exposures on the expression of the human receptor and proteases involved in SARS-CoV-2 cell-entry
Manon Watzky[SUP] 1 [/SUP], Maud de Dieuleveult[SUP] 1 [/SUP], Anne Letessier[SUP] 1 [/SUP], Claude Saint-Ruf[SUP] 1 [/SUP], Benoit Miotto[SUP] 2 [/SUP]
Affiliations
- PMID: 33069705
- PMCID: PMC7560643
- DOI: 10.1016/j.envres.2020.110317
Abstract
The role of environmental condition on the infection by the novel pathogenic SARS-CoV-2 virus remains uncertain. In here, exploiting a large panel of publicly available genome-wide data, we investigated whether the human receptor ACE2 and human proteases TMPRSS2, FURIN and CATHEPSINs (B, L and V), which are involved in SARS-CoV-2 cell entry, are transcriptionally regulated by environmental cues. We report that more than 50 chemicals modulate the expression of ACE2 or human proteases important for SARS-CoV-2 cell entry. We further demonstrate that transcription factor AhR, which is commonly activated by pollutants, binds to the promoter of TMPRSS2 and enhancers and/or promoters of Cathepsin B, L and V encoding genes. Our exploratory study documents an influence of environmental exposures on the expression of genes involved in SARS-CoV-2 cell entry. These results could be conceptually and medically relevant to our understanding of the COVID-19 disease, and should be further explored in laboratory and epidemiologic studies.
Keywords: ACE2; COVID-19; Cathepsin genes; Coronavirus; Environmental exposure; FURIN; SARS-CoV-2; TMPRSS2.