tetano
Editor, Senior Moderator
Epidemiol Infect. 2017 Dec 6:1-11. doi: 10.1017/S0950268817002709. [Epub ahead of print]
[h=1]Estimating vaccine effectiveness against laboratory-confirmed influenza among children and adolescents in Lower Saxony and Saxony-Anhalt, 2012-2016.[/h] M?hl A[SUP]1[/SUP], Gr?fe L[SUP]2[/SUP], Helmeke C[SUP]2[/SUP], Ziehm D[SUP]1[/SUP], Monazahian M[SUP]1[/SUP], Irmscher HM[SUP]2[/SUP], Dreesman J[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza vaccine effectiveness (VE) has to be estimated anew for every season to explore vaccines' protective effect in the population. We report VE estimates against laboratory-confirmed influenza A(H1N1)pdm09, A(H3N2) and influenza B among children aged 2-17 years, using test-negative design. Pooled data from two German federal states' surveillance systems for acute respiratory illness from week 40/2012 to 20/2016 was used, yielding a total of 10 627 specimens. Odds ratios and 95% confidence intervals (95% CIs) for the association between laboratory-confirmed influenza and vaccination status were calculated by multivariate logistic regression adjusting for age, sex, illness onset and federal state. VE was estimated as 1-Odds Ratio. Overall adjusted VE was 33% (95% CI: 24?3-40?7). A strong variation of VE between the seasons and subtypes was observed: highest season- and subtype-specific VE of 86?2% (95% CI: 41?3-96?7) was found against A(H1N1)pdm09 in 7-17-year-olds in 2015/16. Low estimates of VE were observed against A(H3N2) in any season, e.g. 1?5% (95% CI: -39?3-30?3) in 2014/15. Estimates showed a tendency to higher VE among 7-17-year-old children, but differences were not statistically significant. Although our findings are common in studies estimating influenza VE, we discussed several explanations for observed low VE.
[h=4]KEYWORDS:[/h] Epidemiology; influenza (seasonal); routine surveillance data; test-negative design; vaccine effectiveness
PMID: 29208075 DOI: 10.1017/S0950268817002709
[h=1]Estimating vaccine effectiveness against laboratory-confirmed influenza among children and adolescents in Lower Saxony and Saxony-Anhalt, 2012-2016.[/h] M?hl A[SUP]1[/SUP], Gr?fe L[SUP]2[/SUP], Helmeke C[SUP]2[/SUP], Ziehm D[SUP]1[/SUP], Monazahian M[SUP]1[/SUP], Irmscher HM[SUP]2[/SUP], Dreesman J[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza vaccine effectiveness (VE) has to be estimated anew for every season to explore vaccines' protective effect in the population. We report VE estimates against laboratory-confirmed influenza A(H1N1)pdm09, A(H3N2) and influenza B among children aged 2-17 years, using test-negative design. Pooled data from two German federal states' surveillance systems for acute respiratory illness from week 40/2012 to 20/2016 was used, yielding a total of 10 627 specimens. Odds ratios and 95% confidence intervals (95% CIs) for the association between laboratory-confirmed influenza and vaccination status were calculated by multivariate logistic regression adjusting for age, sex, illness onset and federal state. VE was estimated as 1-Odds Ratio. Overall adjusted VE was 33% (95% CI: 24?3-40?7). A strong variation of VE between the seasons and subtypes was observed: highest season- and subtype-specific VE of 86?2% (95% CI: 41?3-96?7) was found against A(H1N1)pdm09 in 7-17-year-olds in 2015/16. Low estimates of VE were observed against A(H3N2) in any season, e.g. 1?5% (95% CI: -39?3-30?3) in 2014/15. Estimates showed a tendency to higher VE among 7-17-year-old children, but differences were not statistically significant. Although our findings are common in studies estimating influenza VE, we discussed several explanations for observed low VE.
[h=4]KEYWORDS:[/h] Epidemiology; influenza (seasonal); routine surveillance data; test-negative design; vaccine effectiveness
PMID: 29208075 DOI: 10.1017/S0950268817002709