tetano
Editor, Senior Moderator
Eur J Clin Microbiol Infect Dis
. 2022 Aug 4.
doi: 10.1007/s10096-022-04478-5. Online ahead of print.
Genome-wide association study of SARS-CoV-2 infection in Chinese population
Jie Fan[SUP] 1 2 [/SUP], Quan-Xin Long[SUP] 3 [/SUP], Ji-Hua Ren[SUP] 3 [/SUP], Hao Chen[SUP] 1 [/SUP], Meng-Meng Li[SUP] 1 [/SUP], Zheng Cheng[SUP] 1 [/SUP], Juan Chen[SUP] 4 5 [/SUP], Li Zhou[SUP] 6 [/SUP], Ai-Long Huang[SUP] 7 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) is a global public health concern. The purpose of this study was to investigate the association between genetic variants and SARS-CoV-2 infection and the COVID-19 severity in Chinese population. A total of 256 individuals including 87 symptomatic patients (tested positive for SARS-CoV-2), 84 asymptomatic cases, and 85 close contacts of confirmed patients (tested negative for SARS-CoV-2) were recruited from February 2020 to May 2020. We carried out the whole exome genome sequencing between the individuals and conducted a genetic association study for SARS-CoV-2 infection and the COVID-19 severity. In total, we analyzed more than 100,000 single-nucleotide polymorphisms. The genome-wide association study suggested potential correlation between genetic variability in POLR2A, ANKRD27, MAN1A2, and ERAP1 genes and SARS-CoV-2 infection susceptibility. The most significant gene locus associated with SARS-CoV-2 infection was located in POLR2A (p = 5.71 × 10[SUP]-6[/SUP]). Furthermore, genetic variants in PCNX2, CD200R1L, ZMAT3, PLCL2, NEIL3, and LINC00700 genes (p < 1 × 10[SUP]-5[/SUP]) were closely associated with the COVID-19 severity in Chinese population. Our study confirmed that new genetic variant loci had significant association with SARS-CoV-2 infection and the COVID-19 severity in Chinese population, which provided new clues for the studies on the susceptibility of SARS-CoV-2 infection and the COVID-19 severity. These findings may give a better understanding on the molecular pathogenesis of COVID-19 and genetic basis of heterogeneous susceptibility, with potential impact on new therapeutic options.
Keywords: COVID-19; GWAS; SARS-CoV2; Severity; Susceptibility.
. 2022 Aug 4.
doi: 10.1007/s10096-022-04478-5. Online ahead of print.
Genome-wide association study of SARS-CoV-2 infection in Chinese population
Jie Fan[SUP] 1 2 [/SUP], Quan-Xin Long[SUP] 3 [/SUP], Ji-Hua Ren[SUP] 3 [/SUP], Hao Chen[SUP] 1 [/SUP], Meng-Meng Li[SUP] 1 [/SUP], Zheng Cheng[SUP] 1 [/SUP], Juan Chen[SUP] 4 5 [/SUP], Li Zhou[SUP] 6 [/SUP], Ai-Long Huang[SUP] 7 [/SUP]
Affiliations
- PMID: 35927536
- DOI: 10.1007/s10096-022-04478-5
Abstract
Coronavirus disease 2019 (COVID-19) is a global public health concern. The purpose of this study was to investigate the association between genetic variants and SARS-CoV-2 infection and the COVID-19 severity in Chinese population. A total of 256 individuals including 87 symptomatic patients (tested positive for SARS-CoV-2), 84 asymptomatic cases, and 85 close contacts of confirmed patients (tested negative for SARS-CoV-2) were recruited from February 2020 to May 2020. We carried out the whole exome genome sequencing between the individuals and conducted a genetic association study for SARS-CoV-2 infection and the COVID-19 severity. In total, we analyzed more than 100,000 single-nucleotide polymorphisms. The genome-wide association study suggested potential correlation between genetic variability in POLR2A, ANKRD27, MAN1A2, and ERAP1 genes and SARS-CoV-2 infection susceptibility. The most significant gene locus associated with SARS-CoV-2 infection was located in POLR2A (p = 5.71 × 10[SUP]-6[/SUP]). Furthermore, genetic variants in PCNX2, CD200R1L, ZMAT3, PLCL2, NEIL3, and LINC00700 genes (p < 1 × 10[SUP]-5[/SUP]) were closely associated with the COVID-19 severity in Chinese population. Our study confirmed that new genetic variant loci had significant association with SARS-CoV-2 infection and the COVID-19 severity in Chinese population, which provided new clues for the studies on the susceptibility of SARS-CoV-2 infection and the COVID-19 severity. These findings may give a better understanding on the molecular pathogenesis of COVID-19 and genetic basis of heterogeneous susceptibility, with potential impact on new therapeutic options.
Keywords: COVID-19; GWAS; SARS-CoV2; Severity; Susceptibility.