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Euro Surveill . Strain-dependent variations in replication of European clade 2.3.4.4b influenza A(H5N1) viruses in bovine cells and thermal inactiv

tetano

Editor, Senior Moderator
Euro Surveill


. 2024 Jul;29(30).
doi: 10.2807/1560-7917.ES.2024.29.30.2400436. Strain-dependent variations in replication of European clade 2.3.4.4b influenza A(H5N1) viruses in bovine cells and thermal inactivation in semi-skimmed or whole milk

Diana I Palme[SUP] 1 [/SUP], Juliane Lang[SUP] 1 [/SUP], Dajana Helke[SUP] 1 [/SUP], Maryna Kuryshko[SUP] 1 [/SUP], Elsayed M Abdelwhab[SUP] 1 [/SUP]



Affiliations
Abstract

We investigated the thermostability of four European avian influenza A(H5N1) viruses in whole and semi-skimmed milk and their replication in bovine kidney and lung cells amid the current influenza A(H5N1) dairy cattle outbreak in the United States. Results showed strain-dependent differences in thermal inactivation, particularly in whole milk, and variable replication efficacy in lung cells. These findings support assessing the inactivation of European H5N1 viruses in milk and their replication in bovine cells, aiding biosafety protocols and public health measures.

Keywords: H5N1 clade 2.3.4.4b; bovine cells; cow; influenza A virus; milk; thermostability.

 
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