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Euro Surveill. Two cases of verified clinical failures using internationally recommended first-line cefixime for gonorrhoea treatment, Norway, 2010

Giuseppe

Emeritus
Two cases of verified clinical failures using internationally recommended first-line cefixime for gonorrhoea treatment, Norway, 2010 (Euro Surveill., abstract, edited)


[Source: Eurosurveillance, full text: <cite cite="http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19721">Eurosurveillance - View Article</cite>. Abstract, edited.]

Eurosurveillance, Volume 15, Issue 47, 25 November 2010

Rapid communications

Two cases of verified clinical failures using internationally recommended first-line cefixime for gonorrhoea treatment, Norway, 2010

M Unemo 1, D Golparian 1, G Syversen 2, D F Vestrheim 3,4, H Moi 3,5

1. Swedish Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Microbiology, ?rebro University Hospital, ?rebro, Sweden
2. Department of Microbiology, Oslo University Hospital, Ullev?l, Oslo, Norway
3. Olafiaklinikken, Oslo University Hospital, Oslo, Norway
4. Division of Infectious Disease Control, Norwegian Institute of Public Health, Oslo, Norway
5. Faculty of Medicine, University of Oslo, Oslo, Norway

Citation style for this article: Unemo M, Golparian D, Syversen G, Vestrheim DF, Moi H. Two cases of verified clinical failures using internationally recommended first-line cefixime for gonorrhoea treatment, Norway, 2010. Euro Surveill. 2010;15(47):pii=19721. Available online: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19721

Date of submission: 11 November 2010


Neisseria gonorrhoeae has developed resistance to most of the available therapeutic antimicrobials. The susceptibility to extended-spectrum cephalosporins, the last remaining first-line treatment option, is decreasing globally. This report describes the first two cases outside Japan of verified gonorrhoea clinical failures using internationally recommended first-line cefixime treatment. Enhanced awareness and more frequent follow-up examination, test-of-cure and appropriate verification/falsification of presumed clinical treatment failures, involving several clinical and laboratory parameters should be strongly emphasised worldwide.

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