tetano
Editor, Senior Moderator
Int J Mol Sci. 2017 Aug 7;18(8). pii: E1650. doi: 10.3390/ijms18081650.
[h=1]Evolution of Influenza A Virus by Mutation and Re-Assortment.[/h] Shao W[SUP]1[/SUP], Li X[SUP]2[/SUP], Goraya MU[SUP]3[/SUP], Wang S[SUP]4[/SUP], Chen JL[SUP]5,[/SUP][SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza A virus (IAV), a highly infectious respiratory pathogen, has continued to be a significant threat to global public health. To complete their life cycle, influenza viruses have evolved multiple strategies to interact with a host. A large number of studies have revealed that the evolution of influenza A virus is mainly mediated through the mutation of the virus itself and the re-assortment of viral genomes derived from various strains. The evolution of influenza A virus through these mechanisms causes worldwide annual epidemics and occasional pandemics. Importantly, influenza A virus can evolve from an animal infected pathogen to a human infected pathogen. The highly pathogenic influenza virus has resulted in stupendous economic losses due to its morbidity and mortality both in human and animals. Influenza viruses fall into a category of viruses that can cause zoonotic infection with stable adaptation to human, leading to sustained horizontal transmission. The rapid mutations of influenza A virus result in the loss of vaccine optimal efficacy, and challenge the complete eradication of the virus. In this review, we highlight the current understanding of influenza A virus evolution caused by the mutation and re-assortment of viral genomes. In addition, we discuss the specific mechanisms by which the virus evolves.
[h=4]KEYWORDS:[/h] influenza A virus; mutation; re-assortment; virus-host interaction
PMID: 28783091 DOI: 10.3390/ijms18081650
[h=1]Evolution of Influenza A Virus by Mutation and Re-Assortment.[/h] Shao W[SUP]1[/SUP], Li X[SUP]2[/SUP], Goraya MU[SUP]3[/SUP], Wang S[SUP]4[/SUP], Chen JL[SUP]5,[/SUP][SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza A virus (IAV), a highly infectious respiratory pathogen, has continued to be a significant threat to global public health. To complete their life cycle, influenza viruses have evolved multiple strategies to interact with a host. A large number of studies have revealed that the evolution of influenza A virus is mainly mediated through the mutation of the virus itself and the re-assortment of viral genomes derived from various strains. The evolution of influenza A virus through these mechanisms causes worldwide annual epidemics and occasional pandemics. Importantly, influenza A virus can evolve from an animal infected pathogen to a human infected pathogen. The highly pathogenic influenza virus has resulted in stupendous economic losses due to its morbidity and mortality both in human and animals. Influenza viruses fall into a category of viruses that can cause zoonotic infection with stable adaptation to human, leading to sustained horizontal transmission. The rapid mutations of influenza A virus result in the loss of vaccine optimal efficacy, and challenge the complete eradication of the virus. In this review, we highlight the current understanding of influenza A virus evolution caused by the mutation and re-assortment of viral genomes. In addition, we discuss the specific mechanisms by which the virus evolves.
[h=4]KEYWORDS:[/h] influenza A virus; mutation; re-assortment; virus-host interaction
PMID: 28783091 DOI: 10.3390/ijms18081650