tetano
Editor, Senior Moderator
Viruses. 2019 Sep 10;11(9). pii: E840. doi: 10.3390/v11090840.
[h=1]Exogenous Interleukin-33 Contributes to Protective Immunity via Cytotoxic T-Cell Priming against Mucosal Influenza Viral Infection.[/h] Kim CW[SUP]1[/SUP], Yoo HJ[SUP]2[/SUP], Park JH[SUP]3[/SUP], Oh JE[SUP]4[/SUP], Lee HK[SUP]5,[/SUP][SUP]6,[/SUP][SUP]7[/SUP].
[h=3]Author information[/h] 1 Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea. chaewon.kim@kaist.ac.kr. 2 Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea. yoohyejee@kaist.ac.kr. 3 Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea. janghyun.park@kaist.ac.kr. 4 Graduate School of Medical Science and Engineering, KAIST, Daejeon 34141, Korea. Jieun.oh@kaist.ac.kr. 5 Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea. heungkyu.lee@kaist.ac.kr. 6 Graduate School of Medical Science and Engineering, KAIST, Daejeon 34141, Korea. heungkyu.lee@kaist.ac.kr. 7 KAIST Institute for Health Science and Technology, KAIST, Daejeon 34141, Korea. heungkyu.lee@kaist.ac.kr.
[h=3]Abstract[/h] Influenza is an infectious respiratory illness caused by the influenza virus. Though vaccines against influenza exist, they have limited efficacy. To additionally develop effective treatments, there is a need to study the mechanisms of host defenses from influenza viral infections. To date, the mechanism by which interleukin (IL)-33 modulates the antiviral immune response post-influenza infection is unclear. In this study, we demonstrate that exogenous IL-33 enhanced antiviral protection against influenza virus infection. Exogenous IL-33 induced the recruitment of dendritic cells, increased the secretion of pro-inflammatory cytokine IL-12, and promoted cytotoxic T-cell responses in the local microenvironment. Thus, our findings suggest a role of exogenous IL-33 in the antiviral immune response against influenza infection.
[h=4]KEYWORDS:[/h] IL-33; antiviral immunity; influenza virus
PMID: 31509992 DOI: 10.3390/v11090840
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[h=1]Exogenous Interleukin-33 Contributes to Protective Immunity via Cytotoxic T-Cell Priming against Mucosal Influenza Viral Infection.[/h] Kim CW[SUP]1[/SUP], Yoo HJ[SUP]2[/SUP], Park JH[SUP]3[/SUP], Oh JE[SUP]4[/SUP], Lee HK[SUP]5,[/SUP][SUP]6,[/SUP][SUP]7[/SUP].
[h=3]Author information[/h] 1 Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea. chaewon.kim@kaist.ac.kr. 2 Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea. yoohyejee@kaist.ac.kr. 3 Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea. janghyun.park@kaist.ac.kr. 4 Graduate School of Medical Science and Engineering, KAIST, Daejeon 34141, Korea. Jieun.oh@kaist.ac.kr. 5 Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea. heungkyu.lee@kaist.ac.kr. 6 Graduate School of Medical Science and Engineering, KAIST, Daejeon 34141, Korea. heungkyu.lee@kaist.ac.kr. 7 KAIST Institute for Health Science and Technology, KAIST, Daejeon 34141, Korea. heungkyu.lee@kaist.ac.kr.
[h=3]Abstract[/h] Influenza is an infectious respiratory illness caused by the influenza virus. Though vaccines against influenza exist, they have limited efficacy. To additionally develop effective treatments, there is a need to study the mechanisms of host defenses from influenza viral infections. To date, the mechanism by which interleukin (IL)-33 modulates the antiviral immune response post-influenza infection is unclear. In this study, we demonstrate that exogenous IL-33 enhanced antiviral protection against influenza virus infection. Exogenous IL-33 induced the recruitment of dendritic cells, increased the secretion of pro-inflammatory cytokine IL-12, and promoted cytotoxic T-cell responses in the local microenvironment. Thus, our findings suggest a role of exogenous IL-33 in the antiviral immune response against influenza infection.
[h=4]KEYWORDS:[/h] IL-33; antiviral immunity; influenza virus
PMID: 31509992 DOI: 10.3390/v11090840
Free full text