tetano
Editor, Senior Moderator
Expert Rev Gastroenterol Hepatol
. 2023 Apr 22.
doi: 10.1080/17474124.2023.2206564. Online ahead of print.
Investigating the correlation between COVID-19 and the progression of chronic liver disease
Cyriac Abby Philips[SUP] 1 [/SUP], Deepak Madhu[SUP] 2 [/SUP], Philip Augustine[SUP] 3 [/SUP]
Affiliations
Abstract
Introduction: The novel coronavirus disease 2019 has thrown light on various heterogeneous afflictions of newly emerging viruses on the human body. Early reports demonstrated direct effect of novel coronavirus on the liver, but subsequently, this did not stand up to validation. The SARS-CoV-2 virus affects the liver differentially; in healthy compared to those with pre-existing liver disease.
Areas covered: This exhaustive paper reviews the current, literature on mechanisms by which COVID-19 affects the healthy liver and those with pre-existing liver disease such as alcohol-related and non-alcoholic fatty liver, autoimmune liver disease, chronic liver disease and cirrhosis, hepatocellular carcinoma, viral hepatitis, and liver transplant recipients, with special mention on drug-and herb-induced liver injury with COVID-19 therapies. Search methodology: the review (Dec. 2022 - Jan. 2023) is based on PubMed (NLM) search using the keyword 'COVID' with supplementary searches using 'fibrosis'; 'liver'; 'cirrhosis'; 'CLD'; 'NAFLD'; 'NASH'; 'hepatocellular carcinoma'; 'hepatitis'; 'fatty liver'; 'alcohol'; 'viral'; 'transplant'; and 'liver failure.'
Expert opinion: Direct liver tropism of SARS-CoV-2 does not cause liver damage. Adverse events following infection depend on the severity of liver disease, the severity of COVID-19, and other risk factors such as metabolic syndrome and older age. Alcohol-related liver disease independently predicts adverse outcomes.
Keywords: DILI; HBV; HCV; cirrhosis; coronavirus; covid vaccine; hepatocellular carcinoma; portal hypertension.
. 2023 Apr 22.
doi: 10.1080/17474124.2023.2206564. Online ahead of print.
Investigating the correlation between COVID-19 and the progression of chronic liver disease
Cyriac Abby Philips[SUP] 1 [/SUP], Deepak Madhu[SUP] 2 [/SUP], Philip Augustine[SUP] 3 [/SUP]
Affiliations
- PMID: 37086388
- DOI: 10.1080/17474124.2023.2206564
Abstract
Introduction: The novel coronavirus disease 2019 has thrown light on various heterogeneous afflictions of newly emerging viruses on the human body. Early reports demonstrated direct effect of novel coronavirus on the liver, but subsequently, this did not stand up to validation. The SARS-CoV-2 virus affects the liver differentially; in healthy compared to those with pre-existing liver disease.
Areas covered: This exhaustive paper reviews the current, literature on mechanisms by which COVID-19 affects the healthy liver and those with pre-existing liver disease such as alcohol-related and non-alcoholic fatty liver, autoimmune liver disease, chronic liver disease and cirrhosis, hepatocellular carcinoma, viral hepatitis, and liver transplant recipients, with special mention on drug-and herb-induced liver injury with COVID-19 therapies. Search methodology: the review (Dec. 2022 - Jan. 2023) is based on PubMed (NLM) search using the keyword 'COVID' with supplementary searches using 'fibrosis'; 'liver'; 'cirrhosis'; 'CLD'; 'NAFLD'; 'NASH'; 'hepatocellular carcinoma'; 'hepatitis'; 'fatty liver'; 'alcohol'; 'viral'; 'transplant'; and 'liver failure.'
Expert opinion: Direct liver tropism of SARS-CoV-2 does not cause liver damage. Adverse events following infection depend on the severity of liver disease, the severity of COVID-19, and other risk factors such as metabolic syndrome and older age. Alcohol-related liver disease independently predicts adverse outcomes.
Keywords: DILI; HBV; HCV; cirrhosis; coronavirus; covid vaccine; hepatocellular carcinoma; portal hypertension.