tetano
Editor, Senior Moderator
Expert Rev Vaccines
. 2024 Jan-Dec;23(1):371-379.
doi: 10.1080/14760584.2024.2330643. Epub 2024 Mar 18. Influenza burden averted with a cell-based quadrivalent seasonal influenza vaccine compared with egg-based quadrivalent seasonal influenza vaccine
Ian McGovern[SUP] 1 [/SUP], Alexandra Taylor[SUP] 2 [/SUP], Aditya Sardesai[SUP] 2 [/SUP], Hector Toro-Diaz[SUP] 3 [/SUP], Mendel Haag[SUP] 4 [/SUP]
Affiliations
Background: Cell-based quadrivalent inactivated influenza vaccines (IIV4c) avoid egg-adaptive mutations found in egg-based production, improving vaccine effectiveness (VE). Studies demonstrate improved VE for IIV4c relative to egg-based quadrivalent inactivated influenza vaccines (IIV4).
Research design and methods: We built on a static compartmental model developed by the CDC to estimate the influenza burden in persons 0-64 years that would be additionally averted by vaccination with IIV4c vs. IIV4. Model inputs were based on published data from 2017-2018, 2018-2019, and 2019-2020 Northern Hemisphere influenza seasons for the US.
Results: Over 3 influenza seasons, relative to IIV4, IIV4c would avert 31-39% more symptomatic cases, 29-40% more outpatient visits, 29-38% more hospitalizations and ICU admissions, and 34-49% more deaths vs. IIV4. In a deterministic sensitivity analysis, the main drivers were the relative VE of IIV4c vs. IIV4 in the 2017-2018 season and influenza burden estimates for the 2018-2019 and 2019-2020 seasons. Probabilistic sensitivity analysis showed that the interquartile range of symptomatic cases was ± 13% of baseline in 2017-2018, ±8% in 2018-2019, and ± 7% in 2019-2020.
Conclusions: IIV4c prevented significantly more symptomatic cases, outpatient visits, hospitalizations, and deaths than IIV4 in persons aged 0-64 years over 3 influenza seasons.
Keywords: Influenza burden; cell-based influenza vaccine; influenza hospitalizations; influenza prevention; seasonal influenza; static compartmental model.
. 2024 Jan-Dec;23(1):371-379.
doi: 10.1080/14760584.2024.2330643. Epub 2024 Mar 18. Influenza burden averted with a cell-based quadrivalent seasonal influenza vaccine compared with egg-based quadrivalent seasonal influenza vaccine
Ian McGovern[SUP] 1 [/SUP], Alexandra Taylor[SUP] 2 [/SUP], Aditya Sardesai[SUP] 2 [/SUP], Hector Toro-Diaz[SUP] 3 [/SUP], Mendel Haag[SUP] 4 [/SUP]
Affiliations
- PMID: 38494917
- DOI: 10.1080/14760584.2024.2330643
Background: Cell-based quadrivalent inactivated influenza vaccines (IIV4c) avoid egg-adaptive mutations found in egg-based production, improving vaccine effectiveness (VE). Studies demonstrate improved VE for IIV4c relative to egg-based quadrivalent inactivated influenza vaccines (IIV4).
Research design and methods: We built on a static compartmental model developed by the CDC to estimate the influenza burden in persons 0-64 years that would be additionally averted by vaccination with IIV4c vs. IIV4. Model inputs were based on published data from 2017-2018, 2018-2019, and 2019-2020 Northern Hemisphere influenza seasons for the US.
Results: Over 3 influenza seasons, relative to IIV4, IIV4c would avert 31-39% more symptomatic cases, 29-40% more outpatient visits, 29-38% more hospitalizations and ICU admissions, and 34-49% more deaths vs. IIV4. In a deterministic sensitivity analysis, the main drivers were the relative VE of IIV4c vs. IIV4 in the 2017-2018 season and influenza burden estimates for the 2018-2019 and 2019-2020 seasons. Probabilistic sensitivity analysis showed that the interquartile range of symptomatic cases was ± 13% of baseline in 2017-2018, ±8% in 2018-2019, and ± 7% in 2019-2020.
Conclusions: IIV4c prevented significantly more symptomatic cases, outpatient visits, hospitalizations, and deaths than IIV4 in persons aged 0-64 years over 3 influenza seasons.
Keywords: Influenza burden; cell-based influenza vaccine; influenza hospitalizations; influenza prevention; seasonal influenza; static compartmental model.