tetano
Editor, Senior Moderator
F1000Res
. 2021 Mar 10;10:196.
doi: 10.12688/f1000research.51479.1. eCollection 2021.
Most Japanese individuals are genetically predisposed to recognize an immunogenic protein fragment shared between COVID-19 and common cold coronaviruses
Johannes M Dijkstra[SUP] 1 [/SUP], Aaron P Frenette[SUP] 2 [/SUP], Brian Dixon[SUP] 2 [/SUP]
Affiliations
Abstract
In the spring of 2020, we and others hypothesized that T cells in COVID-19 patients may recognize identical protein fragments shared between the coronaviruses of the common cold and COVID-19 and thereby confer cross-virus immune memory. Here, we look at this issue by screening studies that, since that time, have experimentally addressed COVID-19 associated T cell specificities. Currently, the identical T cell epitope shared between COVID-19 and common cold coronaviruses most convincingly identified as immunogenic is the CD8 [SUP]+[/SUP] T cell epitope VYIGDPAQL if presented by the MHC class I allele HLA-A*24:02. The HLA-A*24:02 allele is found in the majority of Japanese individuals and several indigenous populations in Asia, Oceania, and the Americas. In combination with histories of common cold infections, HLA-A*24:02 may affect their protection from COVID-19.
Keywords: COVID-19; HLA; Japanese; MHC; SPRWYFYYL; T cell; VYIGDPAQL; epitope; peptide.
. 2021 Mar 10;10:196.
doi: 10.12688/f1000research.51479.1. eCollection 2021.
Most Japanese individuals are genetically predisposed to recognize an immunogenic protein fragment shared between COVID-19 and common cold coronaviruses
Johannes M Dijkstra[SUP] 1 [/SUP], Aaron P Frenette[SUP] 2 [/SUP], Brian Dixon[SUP] 2 [/SUP]
Affiliations
- PMID: 34026045
- PMCID: PMC8108557
- DOI: 10.12688/f1000research.51479.1
Abstract
In the spring of 2020, we and others hypothesized that T cells in COVID-19 patients may recognize identical protein fragments shared between the coronaviruses of the common cold and COVID-19 and thereby confer cross-virus immune memory. Here, we look at this issue by screening studies that, since that time, have experimentally addressed COVID-19 associated T cell specificities. Currently, the identical T cell epitope shared between COVID-19 and common cold coronaviruses most convincingly identified as immunogenic is the CD8 [SUP]+[/SUP] T cell epitope VYIGDPAQL if presented by the MHC class I allele HLA-A*24:02. The HLA-A*24:02 allele is found in the majority of Japanese individuals and several indigenous populations in Asia, Oceania, and the Americas. In combination with histories of common cold infections, HLA-A*24:02 may affect their protection from COVID-19.
Keywords: COVID-19; HLA; Japanese; MHC; SPRWYFYYL; T cell; VYIGDPAQL; epitope; peptide.