tetano
Editor, Senior Moderator
Vaccines (Basel). 2019 Sep 24;7(4). pii: E127. doi: 10.3390/vaccines7040127.
[h=1]Food Additives as Novel Influenza Vaccine Adjuvants.[/h] Feng H[SUP]1[/SUP], Yamashita M[SUP]2[/SUP], Wu L[SUP]3[/SUP], Jose da Silva Lopes T[SUP]4[/SUP], Watanabe T[SUP]5[/SUP], Kawaoka Y[SUP]6,[/SUP][SUP]7,[/SUP][SUP]8[/SUP].
[h=3]Author information[/h] 1 Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan. hpfeng@ims.u-tokyo.ac.jp. 2 Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan. yamakoto@ims.u-tokyo.ac.jp. 3 Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan. lwu19870426@gmail.com. 4 Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53711, USA. tiagojose.dasilvalopes@wisc.edu. 5 Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan. tokikow@ims.u-tokyo.ac.jp. 6 Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan. yoshihiro.kawaoka@wisc.edu. 7 Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53711, USA. yoshihiro.kawaoka@wisc.edu. 8 Department of Special Pathogens, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan. yoshihiro.kawaoka@wisc.edu.
[h=3]Abstract[/h] Influenza is a major threat to public health. Vaccination is an effective strategy to control influenza; however, the current inactivated influenza vaccine has mild immunogenicity and exhibits suboptimal efficacy in clinical use. Vaccine efficacy can be improved by the addition of adjuvants, but few adjuvants have been approved for human use. To explore novel and effective adjuvants for influenza vaccines, here we screened 145 compounds from food additives approved in Japan. Of these 145 candidates, we identified 41 compounds that enhanced the efficacy of the split influenza hemagglutinin (HA) vaccine against lethal virus challenge in a mouse model. These 41 compounds included 18 novel adjuvant candidates and 15 compounds with previously reported adjuvant effects for other antigens but not for the influenza vaccine. Our results are of value to the development of novel and effective adjuvanted influenza or other vaccines for human use.
[h=4]KEYWORDS:[/h] adjuvants; food additives; influenza; mice; vaccine
PMID: 31554190 DOI: 10.3390/vaccines7040127
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[h=1]Food Additives as Novel Influenza Vaccine Adjuvants.[/h] Feng H[SUP]1[/SUP], Yamashita M[SUP]2[/SUP], Wu L[SUP]3[/SUP], Jose da Silva Lopes T[SUP]4[/SUP], Watanabe T[SUP]5[/SUP], Kawaoka Y[SUP]6,[/SUP][SUP]7,[/SUP][SUP]8[/SUP].
[h=3]Author information[/h] 1 Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan. hpfeng@ims.u-tokyo.ac.jp. 2 Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan. yamakoto@ims.u-tokyo.ac.jp. 3 Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan. lwu19870426@gmail.com. 4 Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53711, USA. tiagojose.dasilvalopes@wisc.edu. 5 Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan. tokikow@ims.u-tokyo.ac.jp. 6 Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan. yoshihiro.kawaoka@wisc.edu. 7 Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53711, USA. yoshihiro.kawaoka@wisc.edu. 8 Department of Special Pathogens, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan. yoshihiro.kawaoka@wisc.edu.
[h=3]Abstract[/h] Influenza is a major threat to public health. Vaccination is an effective strategy to control influenza; however, the current inactivated influenza vaccine has mild immunogenicity and exhibits suboptimal efficacy in clinical use. Vaccine efficacy can be improved by the addition of adjuvants, but few adjuvants have been approved for human use. To explore novel and effective adjuvants for influenza vaccines, here we screened 145 compounds from food additives approved in Japan. Of these 145 candidates, we identified 41 compounds that enhanced the efficacy of the split influenza hemagglutinin (HA) vaccine against lethal virus challenge in a mouse model. These 41 compounds included 18 novel adjuvant candidates and 15 compounds with previously reported adjuvant effects for other antigens but not for the influenza vaccine. Our results are of value to the development of novel and effective adjuvanted influenza or other vaccines for human use.
[h=4]KEYWORDS:[/h] adjuvants; food additives; influenza; mice; vaccine
PMID: 31554190 DOI: 10.3390/vaccines7040127
Free full text