tetano
Editor, Senior Moderator
Nat Commun. 2014 Mar 17;5:3495. doi: 10.1038/ncomms4495.
FoxP3+ regulatory T cells promote influenza-specific Tfh responses by controlling IL-2 availability.
Le?n B1, Bradley JE2, Lund FE1, Randall TD2, Ballesteros-Tato A2.
Author information
Abstract
Here, we test the role of FoxP3(+) regulatory T cells (Tregs) in controlling T follicular helper (Tfh) and germinal centre (GC) B-cell responses to influenza. In contrast to the idea that Tregs suppress T-cell responses, we find that Treg depletion severely reduces the Tfh cell response to influenza virus. Furthermore, Treg depletion prevents the accumulation of influenza-specific GCs. These effects are not due to alterations in TGFβ availability or a precursor-progeny relationship between Tregs and Tfh cells, but are instead mediated by increased availability of IL-2, which suppresses the differentiation of Tfh cells and as a consequence, compromises the GC B response. Thus, Tregs promote influenza-specific GC responses by preventing excessive IL-2 signalling, which suppresses Tfh cell differentiation.
PMID:
24633065
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/24633065
FoxP3+ regulatory T cells promote influenza-specific Tfh responses by controlling IL-2 availability.
Le?n B1, Bradley JE2, Lund FE1, Randall TD2, Ballesteros-Tato A2.
Author information
Abstract
Here, we test the role of FoxP3(+) regulatory T cells (Tregs) in controlling T follicular helper (Tfh) and germinal centre (GC) B-cell responses to influenza. In contrast to the idea that Tregs suppress T-cell responses, we find that Treg depletion severely reduces the Tfh cell response to influenza virus. Furthermore, Treg depletion prevents the accumulation of influenza-specific GCs. These effects are not due to alterations in TGFβ availability or a precursor-progeny relationship between Tregs and Tfh cells, but are instead mediated by increased availability of IL-2, which suppresses the differentiation of Tfh cells and as a consequence, compromises the GC B response. Thus, Tregs promote influenza-specific GC responses by preventing excessive IL-2 signalling, which suppresses Tfh cell differentiation.
PMID:
24633065
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/24633065