tetano
Editor, Senior Moderator
Emerg Infect Dis. 2018 Oct;24(10):1825-1834. doi: 10.3201/eid2410.180652.
[h=1]Frequent Genetic Mismatch between Vaccine Strains and Circulating Seasonal Influenza Viruses, Hong Kong, China, 1996-2012.[/h] Chan MCW, Wang MH, Chen Z, Hui DSC, Kwok AK, Yeung ACM, Liu KM, Yeoh YK, Lee N, Chan PKS.
[h=3]Abstract[/h] The World Health Organization selects influenza vaccine compositions biannually to cater to peaks in temperate regions. In tropical and subtropical regions, where influenza seasonality varies and epidemics can occur year-round, the choice of vaccine remains uncertain. Our 17-year molecular epidemiologic survey showed that most influenza A(H3N2) (9/11) and B (6/7) vaccine strains had circulated in East Asia >1 year before inclusion into vaccines. Northern Hemisphere vaccine strains and circulating strains in East Asia were closely matched in 7 (20.6%) of 34 seasons for H3N2 and 5 (14.7%) of 34 seasons for B. Southern Hemisphere vaccines also had a low probability of matching (H3N2, 14.7%; B, 11.1%). Strain drift among seasons was common (H3N2, 41.2%; B, 35.3%), and biannual vaccination strategy (Northern Hemisphere vaccines in November followed by Southern Hemisphere vaccines in May) did not improve matching. East Asia is an important contributor to influenza surveillance but often has mismatch between vaccine and contemporarily circulating strains.
[h=4]KEYWORDS:[/h] China; Hong Kong; Molecular epidemiology; antigenic drift; genetic drift; hemagglutinin; influenza; subtropics; vaccination; vaccines; viruses
PMID: 30226188 DOI: 10.3201/eid2410.180652
Free full text
[h=1]Frequent Genetic Mismatch between Vaccine Strains and Circulating Seasonal Influenza Viruses, Hong Kong, China, 1996-2012.[/h] Chan MCW, Wang MH, Chen Z, Hui DSC, Kwok AK, Yeung ACM, Liu KM, Yeoh YK, Lee N, Chan PKS.
[h=3]Abstract[/h] The World Health Organization selects influenza vaccine compositions biannually to cater to peaks in temperate regions. In tropical and subtropical regions, where influenza seasonality varies and epidemics can occur year-round, the choice of vaccine remains uncertain. Our 17-year molecular epidemiologic survey showed that most influenza A(H3N2) (9/11) and B (6/7) vaccine strains had circulated in East Asia >1 year before inclusion into vaccines. Northern Hemisphere vaccine strains and circulating strains in East Asia were closely matched in 7 (20.6%) of 34 seasons for H3N2 and 5 (14.7%) of 34 seasons for B. Southern Hemisphere vaccines also had a low probability of matching (H3N2, 14.7%; B, 11.1%). Strain drift among seasons was common (H3N2, 41.2%; B, 35.3%), and biannual vaccination strategy (Northern Hemisphere vaccines in November followed by Southern Hemisphere vaccines in May) did not improve matching. East Asia is an important contributor to influenza surveillance but often has mismatch between vaccine and contemporarily circulating strains.
[h=4]KEYWORDS:[/h] China; Hong Kong; Molecular epidemiology; antigenic drift; genetic drift; hemagglutinin; influenza; subtropics; vaccination; vaccines; viruses
PMID: 30226188 DOI: 10.3201/eid2410.180652
Free full text