tetano
Editor, Senior Moderator
Front Cell Dev Biol
. 2022 Feb 11;10:807149.
doi: 10.3389/fcell.2022.807149. eCollection 2022.
Protein Posttranslational Signatures Identified in COVID-19 Patient Plasma
Pavan Vedula[SUP] 1 [/SUP], Hsin-Yao Tang[SUP] 2 [/SUP], David W Speicher[SUP] 2 [/SUP], Anna Kashina[SUP] 1 [/SUP], UPenn COVID Processing Unit
Affiliations
Abstract
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a highly contagious virus of the coronavirus family that causes coronavirus disease-19 (COVID-19) in humans and a number of animal species. COVID-19 has rapidly propagated in the world in the past 2 years, causing a global pandemic. Here, we performed proteomic analysis of plasma samples from COVID-19 patients compared to healthy control donors in an exploratory study to gain insights into protein-level changes in the patients caused by SARS-CoV-2 infection and to identify potential proteomic and posttranslational signatures of this disease. Our results suggest a global change in protein processing and regulation that occurs in response to SARS-CoV-2, and the existence of a posttranslational COVID-19 signature that includes an elevation in threonine phosphorylation, a change in glycosylation, and a decrease in arginylation, an emerging posttranslational modification not previously implicated in infectious disease. This study provides a resource for COVID-19 researchers and, longer term, and will inform our understanding of this disease and its treatment.
Keywords: COVID-19; arginylation; peptidomics; posttranslational modifications; proteomics.
. 2022 Feb 11;10:807149.
doi: 10.3389/fcell.2022.807149. eCollection 2022.
Protein Posttranslational Signatures Identified in COVID-19 Patient Plasma
Pavan Vedula[SUP] 1 [/SUP], Hsin-Yao Tang[SUP] 2 [/SUP], David W Speicher[SUP] 2 [/SUP], Anna Kashina[SUP] 1 [/SUP], UPenn COVID Processing Unit
Affiliations
- PMID: 35223838
- PMCID: PMC8873527
- DOI: 10.3389/fcell.2022.807149
Abstract
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a highly contagious virus of the coronavirus family that causes coronavirus disease-19 (COVID-19) in humans and a number of animal species. COVID-19 has rapidly propagated in the world in the past 2 years, causing a global pandemic. Here, we performed proteomic analysis of plasma samples from COVID-19 patients compared to healthy control donors in an exploratory study to gain insights into protein-level changes in the patients caused by SARS-CoV-2 infection and to identify potential proteomic and posttranslational signatures of this disease. Our results suggest a global change in protein processing and regulation that occurs in response to SARS-CoV-2, and the existence of a posttranslational COVID-19 signature that includes an elevation in threonine phosphorylation, a change in glycosylation, and a decrease in arginylation, an emerging posttranslational modification not previously implicated in infectious disease. This study provides a resource for COVID-19 researchers and, longer term, and will inform our understanding of this disease and its treatment.
Keywords: COVID-19; arginylation; peptidomics; posttranslational modifications; proteomics.