tetano
Editor, Senior Moderator
Front Immunol
. 2020 Jul 10;11:1692.
doi: 10.3389/fimmu.2020.01692. eCollection 2020.
The Potential Effect of Novel Coronavirus SARS-CoV-2 on NK Cells; A Perspective on Potential Therapeutic Interventions
Anahid Jewett[SUP] 1 2 [/SUP]
Affiliations
Abstract
Coronavirus-induced disease-2019 (COVID-19) continues to cause significant morbidity and mortality worldwide. While studies on SARS-CoV-2 effects on immune cell function continue to progress, we know very little about the significance of depletion of key immune effectors by the virus in the mortality and morbidity of the disease. This commentary outlines what is the reported literature thus far on the effect of virus on NK cells known to kill virally infected cells. It also underscores the necessity for the future comprehensive studies of NK cells in SARS-CoV-2 infected individuals and animal models to better understand the role and significance of reported NK cell depletion and functional inactivation in disease morbidity and mortality, in hope to design effective therapeutic interventions for the disease.
Keywords: COVID-19; NK cells; SARS-CoV-2; immune cell; virus.
. 2020 Jul 10;11:1692.
doi: 10.3389/fimmu.2020.01692. eCollection 2020.
The Potential Effect of Novel Coronavirus SARS-CoV-2 on NK Cells; A Perspective on Potential Therapeutic Interventions
Anahid Jewett[SUP] 1 2 [/SUP]
Affiliations
- PMID: 32754162
- PMCID: PMC7365845
- DOI: 10.3389/fimmu.2020.01692
Abstract
Coronavirus-induced disease-2019 (COVID-19) continues to cause significant morbidity and mortality worldwide. While studies on SARS-CoV-2 effects on immune cell function continue to progress, we know very little about the significance of depletion of key immune effectors by the virus in the mortality and morbidity of the disease. This commentary outlines what is the reported literature thus far on the effect of virus on NK cells known to kill virally infected cells. It also underscores the necessity for the future comprehensive studies of NK cells in SARS-CoV-2 infected individuals and animal models to better understand the role and significance of reported NK cell depletion and functional inactivation in disease morbidity and mortality, in hope to design effective therapeutic interventions for the disease.
Keywords: COVID-19; NK cells; SARS-CoV-2; immune cell; virus.