tetano
Editor, Senior Moderator
Front Med (Lausanne)
. 2022 Jan 13;8:758414.
doi: 10.3389/fmed.2021.758414. eCollection 2021.
Hyperglycemia and Angiotensin-Converting Enzyme 2 in Pulmonary Function in the Context of SARS-CoV-2 Infection
Jose R Vargas-Rodriguez[SUP] 1 [/SUP], Idalia Garza-Veloz[SUP] 1 [/SUP], Virginia Flores-Morales[SUP] 2 [/SUP], Jose I Badillo-Almaraz[SUP] 1 [/SUP], Maria R Rocha-Pizaña[SUP] 3 [/SUP], José J Valdés-Aguayo[SUP] 1 [/SUP], Margarita L Martinez-Fierro[SUP] 1 [/SUP]
Affiliations
Abstract
Since the appearance of the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2003 in China, diabetes mellitus (DM) and hyperglycemia in patients infected with SARS-CoV, represent independent predictors of mortality. Therefore, metabolic control has played a major role in the prognosis of these patients. In the current pandemic of coronavirus disease 19 (COVID-19), multiple studies have shown that DM is one of the main comorbidities associated with COVID-19 and higher risk of complications and death. The incidence and prevalence of COVID-19 complications and death related with hyperglycemia in patients with or without DM are high. There are many hypotheses related with worse prognosis and death related to COVID-19 and/or hyperglycemia. However, the information about the interplay between hyperglycemia and angiotensin-converting enzyme 2 (ACE2), the critical receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in the context of SARS-CoV-2 infection, is almost null, but there is enough information to consider the possible participation of hyperglycemia in the glycation of this protein, unleashing a pool of reactions leading to acute respiratory distress syndrome and death in patients with COVID-19. In this document we investigated the current evidence related with ACE2 as a key element within the pathophysiological mechanism related with hyperglycemia extrapolating it to context of SARS-CoV-2 infection and its relationship with worse prognosis and death for COVID-19.
Keywords: ACE2 glycation; COVID-19; SARS-CoV-2; hyperglycemia; non-enzymatic glycation.
. 2022 Jan 13;8:758414.
doi: 10.3389/fmed.2021.758414. eCollection 2021.
Hyperglycemia and Angiotensin-Converting Enzyme 2 in Pulmonary Function in the Context of SARS-CoV-2 Infection
Jose R Vargas-Rodriguez[SUP] 1 [/SUP], Idalia Garza-Veloz[SUP] 1 [/SUP], Virginia Flores-Morales[SUP] 2 [/SUP], Jose I Badillo-Almaraz[SUP] 1 [/SUP], Maria R Rocha-Pizaña[SUP] 3 [/SUP], José J Valdés-Aguayo[SUP] 1 [/SUP], Margarita L Martinez-Fierro[SUP] 1 [/SUP]
Affiliations
- PMID: 35096863
- PMCID: PMC8792738
- DOI: 10.3389/fmed.2021.758414
Abstract
Since the appearance of the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2003 in China, diabetes mellitus (DM) and hyperglycemia in patients infected with SARS-CoV, represent independent predictors of mortality. Therefore, metabolic control has played a major role in the prognosis of these patients. In the current pandemic of coronavirus disease 19 (COVID-19), multiple studies have shown that DM is one of the main comorbidities associated with COVID-19 and higher risk of complications and death. The incidence and prevalence of COVID-19 complications and death related with hyperglycemia in patients with or without DM are high. There are many hypotheses related with worse prognosis and death related to COVID-19 and/or hyperglycemia. However, the information about the interplay between hyperglycemia and angiotensin-converting enzyme 2 (ACE2), the critical receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in the context of SARS-CoV-2 infection, is almost null, but there is enough information to consider the possible participation of hyperglycemia in the glycation of this protein, unleashing a pool of reactions leading to acute respiratory distress syndrome and death in patients with COVID-19. In this document we investigated the current evidence related with ACE2 as a key element within the pathophysiological mechanism related with hyperglycemia extrapolating it to context of SARS-CoV-2 infection and its relationship with worse prognosis and death for COVID-19.
Keywords: ACE2 glycation; COVID-19; SARS-CoV-2; hyperglycemia; non-enzymatic glycation.