tetano
Editor, Senior Moderator
Front Public Health
. 2020 Jun 5;8:267.
doi: 10.3389/fpubh.2020.00267. eCollection 2020.
Identification of RT-PCR-Negative Asymptomatic COVID-19 Patients via Serological Testing
Jinru Wu[SUP] 1 2 [/SUP], Xinyi Liu[SUP] 1 [/SUP], Dan Zhou[SUP] 2 [/SUP], Guangqian Qiu[SUP] 2 [/SUP], Miao Dai[SUP] 2 [/SUP], Qingting Yang[SUP] 2 [/SUP], Zhonghui Pan[SUP] 3 [/SUP], Ning Zhou[SUP] 4 [/SUP], Pa Wu[SUP] 1 [/SUP]
Affiliations
Abstract
Asymptomatic individuals with coronavirus disease (COVID-19) have been identified via nucleic acid testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); however, the epidemiologic characteristics and viral shedding pattern of asymptomatic patients remain largely unknown. In this study, serological testing was applied when identifying nine asymptomatic cases of COVID-19 who showed persistent negative RT-PCR test results for SARS-CoV-2 nucleic acid and no symptoms of COVID-19. Two asymptomatic cases were presumed to be index patients who had cleared the virus when their close contacts developed symptoms of COVID-19. Three of the asymptomatic cases were local individuals who spontaneously recovered before their presumed index patients developed symptoms of COVID-19. This report presents the epidemiologic and clinical characteristics of asymptomatic individuals with SARS-CoV-2 infection that were undetected on RT-PCR tests in previous epidemiologic investigations probably due to the transient viral shedding duration.
Keywords: COVID-19; SARS-CoV-2; asymptomatic; reverse transcription polymerase chain reaction; serological test.
. 2020 Jun 5;8:267.
doi: 10.3389/fpubh.2020.00267. eCollection 2020.
Identification of RT-PCR-Negative Asymptomatic COVID-19 Patients via Serological Testing
Jinru Wu[SUP] 1 2 [/SUP], Xinyi Liu[SUP] 1 [/SUP], Dan Zhou[SUP] 2 [/SUP], Guangqian Qiu[SUP] 2 [/SUP], Miao Dai[SUP] 2 [/SUP], Qingting Yang[SUP] 2 [/SUP], Zhonghui Pan[SUP] 3 [/SUP], Ning Zhou[SUP] 4 [/SUP], Pa Wu[SUP] 1 [/SUP]
Affiliations
- PMID: 32582617
- PMCID: PMC7294962
- DOI: 10.3389/fpubh.2020.00267
Abstract
Asymptomatic individuals with coronavirus disease (COVID-19) have been identified via nucleic acid testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); however, the epidemiologic characteristics and viral shedding pattern of asymptomatic patients remain largely unknown. In this study, serological testing was applied when identifying nine asymptomatic cases of COVID-19 who showed persistent negative RT-PCR test results for SARS-CoV-2 nucleic acid and no symptoms of COVID-19. Two asymptomatic cases were presumed to be index patients who had cleared the virus when their close contacts developed symptoms of COVID-19. Three of the asymptomatic cases were local individuals who spontaneously recovered before their presumed index patients developed symptoms of COVID-19. This report presents the epidemiologic and clinical characteristics of asymptomatic individuals with SARS-CoV-2 infection that were undetected on RT-PCR tests in previous epidemiologic investigations probably due to the transient viral shedding duration.
Keywords: COVID-19; SARS-CoV-2; asymptomatic; reverse transcription polymerase chain reaction; serological test.