tetano
Editor, Senior Moderator
Rev Port Cardiol. 2012 Jun 15. [Epub ahead of print]
Fulminant myocarditis associated with pandemic H1N1 influenza A virus.
[Article in English, Portuguese]
Cabral M, Brito MJ, Conde M, Oliveira M, Ferreira GC.
Source
Department of Pediatrics, Hospital Dona Estef?nia - CHLC - EPE, Lisbon, Portugal.
Abstract
Fulminant myocarditis associated with influenza A virus is exceedingly rare, with only a few cases reported in the literature. We describe a previously healthy 10-year-old boy, with a three-day history of flu-like symptoms without antiviral treatment. He was hospitalized with dehydration and hypothermia in the context of persistent vomiting, when he suddenly developed heart failure secondary to fulminant myocarditis. Despite aggressive management, including circulatory support and cardiopulmonary resuscitation measures, the patient died of cardiogenic shock. The postmortem histopathology was compatible with a multisystem viral infection with myocarditis and pulmonary involvement, and H1N1v polymerase chain reaction was positive. The prevalence of influenza-associated fulminant myocarditis remains unknown. Findings reported in the literature raise the possibility that the novel H1N1 influenza A virus is more commonly associated with a severe form of myocarditis than previously encountered influenza strains.
Copyright ? 2011 Sociedade Portuguesa de Cardiologia. Published by Elsevier Espa?a. All rights reserved.
PMID:
22704822
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22704822
Fulminant myocarditis associated with pandemic H1N1 influenza A virus.
[Article in English, Portuguese]
Cabral M, Brito MJ, Conde M, Oliveira M, Ferreira GC.
Source
Department of Pediatrics, Hospital Dona Estef?nia - CHLC - EPE, Lisbon, Portugal.
Abstract
Fulminant myocarditis associated with influenza A virus is exceedingly rare, with only a few cases reported in the literature. We describe a previously healthy 10-year-old boy, with a three-day history of flu-like symptoms without antiviral treatment. He was hospitalized with dehydration and hypothermia in the context of persistent vomiting, when he suddenly developed heart failure secondary to fulminant myocarditis. Despite aggressive management, including circulatory support and cardiopulmonary resuscitation measures, the patient died of cardiogenic shock. The postmortem histopathology was compatible with a multisystem viral infection with myocarditis and pulmonary involvement, and H1N1v polymerase chain reaction was positive. The prevalence of influenza-associated fulminant myocarditis remains unknown. Findings reported in the literature raise the possibility that the novel H1N1 influenza A virus is more commonly associated with a severe form of myocarditis than previously encountered influenza strains.
Copyright ? 2011 Sociedade Portuguesa de Cardiologia. Published by Elsevier Espa?a. All rights reserved.
PMID:
22704822
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22704822