tetano
Editor, Senior Moderator
Gastroenterology
. 2020 Oct 29;S0016-5085(20)35327-0.
doi: 10.1053/j.gastro.2020.07.067. Online ahead of print.
The Role of Angiotensin Converting Enzyme 2 (ACE2) in Modulating Gut Microbiota, Intestinal Inflammation, and Coronavirus Infection
Josef M Penninger[SUP] 1 [/SUP], Maria B Grant[SUP] 2 [/SUP], Joseph J Y Sung[SUP] 3 [/SUP]
Affiliations
Abstract
The role of angiotensin converting enzyme 2 (ACE2) has expanded from regulating the renin angiotensin system to regulating intestinal amino acid homeostasis and the gut microbiome. Recently, ACE2 was identified as a primary receptor for SARS coronaviruses, SARS-CoV and SARS-CoV-2, being expressed in multiple tissues including the luminal surface of the gut. In this brief perspective, we examine the role of ACE2 as the receptor for SARS-CoV-2 and the impact of COVID-19 infection on the gut microbiome and on the gut epithelium.
. 2020 Oct 29;S0016-5085(20)35327-0.
doi: 10.1053/j.gastro.2020.07.067. Online ahead of print.
The Role of Angiotensin Converting Enzyme 2 (ACE2) in Modulating Gut Microbiota, Intestinal Inflammation, and Coronavirus Infection
Josef M Penninger[SUP] 1 [/SUP], Maria B Grant[SUP] 2 [/SUP], Joseph J Y Sung[SUP] 3 [/SUP]
Affiliations
- PMID: 33130103
- DOI: 10.1053/j.gastro.2020.07.067
Abstract
The role of angiotensin converting enzyme 2 (ACE2) has expanded from regulating the renin angiotensin system to regulating intestinal amino acid homeostasis and the gut microbiome. Recently, ACE2 was identified as a primary receptor for SARS coronaviruses, SARS-CoV and SARS-CoV-2, being expressed in multiple tissues including the luminal surface of the gut. In this brief perspective, we examine the role of ACE2 as the receptor for SARS-CoV-2 and the impact of COVID-19 infection on the gut microbiome and on the gut epithelium.