tetano
Editor, Senior Moderator
Genes Dis
. 2022 Dec 27.
doi: 10.1016/j.gendis.2022.11.016. Online ahead of print.
Advances of CRISPR-Cas13 system in COVID-19 diagnosis and treatment
Qianqian Zhou[SUP] 1 [/SUP], Yanhua Chen[SUP] 1 [/SUP], Ruolei Wang[SUP] 1 [/SUP], Fengjing Jia[SUP] 1 [/SUP], Feng He[SUP] 1 [/SUP], Fuwen Yuan[SUP] 1 [/SUP]
Affiliations
Abstract
The ongoing global pandemic of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in over 570 million infections and 6 million deaths worldwide. Early detection and quarantine are essential to arrest the spread of the highly contagious COVID-19. High-risk groups, such as older adults and individuals with comorbidities, can present severe symptoms, including pyrexia, pertussis, and acute respiratory distress syndrome, on SARS-CoV-2 infection that can prove fatal, demonstrating a clear need for high-throughput and sensitive platforms to detect and eliminate SARS-CoV-2. CRISPR-Cas13, an emerging CRISPR system targeting RNA with high specificity and efficiency, has recently drawn much attention for COVID-19 diagnosis and treatment. Here, we summarized the current research progress on CRISPR-Cas13 in COVID-19 diagnosis and treatment and highlight the challenges and future research directions of CRISPR-Cas13 for effectively counteracting COVID-19.
Keywords: COVID-19; CRISPR-Cas13; Diagnosis; SARS-CoV-2; Treatment.
. 2022 Dec 27.
doi: 10.1016/j.gendis.2022.11.016. Online ahead of print.
Advances of CRISPR-Cas13 system in COVID-19 diagnosis and treatment
Qianqian Zhou[SUP] 1 [/SUP], Yanhua Chen[SUP] 1 [/SUP], Ruolei Wang[SUP] 1 [/SUP], Fengjing Jia[SUP] 1 [/SUP], Feng He[SUP] 1 [/SUP], Fuwen Yuan[SUP] 1 [/SUP]
Affiliations
- PMID: 36591005
- PMCID: PMC9793954
- DOI: 10.1016/j.gendis.2022.11.016
Abstract
The ongoing global pandemic of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in over 570 million infections and 6 million deaths worldwide. Early detection and quarantine are essential to arrest the spread of the highly contagious COVID-19. High-risk groups, such as older adults and individuals with comorbidities, can present severe symptoms, including pyrexia, pertussis, and acute respiratory distress syndrome, on SARS-CoV-2 infection that can prove fatal, demonstrating a clear need for high-throughput and sensitive platforms to detect and eliminate SARS-CoV-2. CRISPR-Cas13, an emerging CRISPR system targeting RNA with high specificity and efficiency, has recently drawn much attention for COVID-19 diagnosis and treatment. Here, we summarized the current research progress on CRISPR-Cas13 in COVID-19 diagnosis and treatment and highlight the challenges and future research directions of CRISPR-Cas13 for effectively counteracting COVID-19.
Keywords: COVID-19; CRISPR-Cas13; Diagnosis; SARS-CoV-2; Treatment.