tetano
Editor, Senior Moderator
Genome
. 2020 Oct 21.
doi: 10.1139/gen-2020-0124. Online ahead of print.
Epigenetic regulation of ACE2, the receptor of the SARS-CoV-2 virus
Tasnim Beacon[SUP] 1 [/SUP], Genevi?ve P Delcuve[SUP] 2 [/SUP], James R Davie[SUP] 3 [/SUP]
Affiliations
Abstract
The angiotensin-converting enzyme 2 (ACE2) is the receptor for the three coronaviruses HCoV-NL63, SARS-CoV and SARS-CoV-2. ACE2 is involved in the regulation of the renin-angiotensin system and blood pressure. ACE2 is also involved in the regulation of several signaling pathways, including integrin signaling. ACE2 expression is regulated transcriptionally and post-transcriptionally. The expression of the gene is regulated by two promoters, with usage varying among tissues. ACE2 expression is greatest in the small intestine, kidney and heart and detectable in a variety of tissues and cell types. Herein we review the chemical and mechanical signal transduction pathways regulating the expression of the ACE2 gene and the epigenetic/chromatin features of the expressed gene.
. 2020 Oct 21.
doi: 10.1139/gen-2020-0124. Online ahead of print.
Epigenetic regulation of ACE2, the receptor of the SARS-CoV-2 virus
Tasnim Beacon[SUP] 1 [/SUP], Genevi?ve P Delcuve[SUP] 2 [/SUP], James R Davie[SUP] 3 [/SUP]
Affiliations
- PMID: 33086021
- DOI: 10.1139/gen-2020-0124
Abstract
The angiotensin-converting enzyme 2 (ACE2) is the receptor for the three coronaviruses HCoV-NL63, SARS-CoV and SARS-CoV-2. ACE2 is involved in the regulation of the renin-angiotensin system and blood pressure. ACE2 is also involved in the regulation of several signaling pathways, including integrin signaling. ACE2 expression is regulated transcriptionally and post-transcriptionally. The expression of the gene is regulated by two promoters, with usage varying among tissues. ACE2 expression is greatest in the small intestine, kidney and heart and detectable in a variety of tissues and cell types. Herein we review the chemical and mechanical signal transduction pathways regulating the expression of the ACE2 gene and the epigenetic/chromatin features of the expressed gene.