tetano
Editor, Senior Moderator
Sci Total Environ. 2015 Jul 11;533:275-282. doi: 10.1016/j.scitotenv.2015.07.001. [Epub ahead of print]
[h=1]Geogenic PM10 exposure exacerbates responses to influenza infection.[/h] Clifford HD[SUP]1[/SUP], Perks KL[SUP]2[/SUP], Zosky GR[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Particulate matter (PM) exposure has been linked epidemiologically to exacerbations of lung disease, including respiratory infections. We investigated the effects of geogenic (earth-derived) PM[SUB]10[/SUB] (PM<10μm diameter) on the response to a respiratory viral infection. Geogenic dust was sampled from four communities in arid environments in Western Australia. Adult female BALB/c mice were intranasally exposed to chronic doses of PM[SUB]10[/SUB] (10μg/day for 10days), and/or infected with influenza (A/Mem/1/71) virus. Inflammation (cells, IL-6, IFN-γ) was measured in bronchoalveolar lavage. Lung mechanics were measured using the forced oscillation technique. Geogenic PM[SUB]10[/SUB] induced lung inflammation (neutrophils, macrophages) with additive effects in mice also infected with influenza. PM[SUB]10[/SUB] also modified the influenza-induced IL-6 and IFN-γ responses. Geogenic PM[SUB]10[/SUB] increased airway resistance, and increased hysteresivity in those exposed to both insults. Viral titres were significantly higher after PM[SUB]10[/SUB] exposure. Iron concentration was inversely associated with IFN-γ and positively associated with viral titre and hysteresivity. Geogenic PM[SUB]10[/SUB] exposure increases inflammation, impairs lung function and increases viral load, exacerbating the response to respiratory viral infection. Iron in the particles may be a driver of these responses. This has important implications for respiratory health in communities exposed to high geogenic PM[SUB]10[/SUB], such as those in arid environments.
Copyright ? 2015. Published by Elsevier B.V.
[h=4]KEYWORDS:[/h] Geogenic; Inflammation; Influenza; Iron; Lung function; Particle; Viral titre
PMID: 26172594 [PubMed - as supplied by publisher]
[h=1]Geogenic PM10 exposure exacerbates responses to influenza infection.[/h] Clifford HD[SUP]1[/SUP], Perks KL[SUP]2[/SUP], Zosky GR[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Particulate matter (PM) exposure has been linked epidemiologically to exacerbations of lung disease, including respiratory infections. We investigated the effects of geogenic (earth-derived) PM[SUB]10[/SUB] (PM<10μm diameter) on the response to a respiratory viral infection. Geogenic dust was sampled from four communities in arid environments in Western Australia. Adult female BALB/c mice were intranasally exposed to chronic doses of PM[SUB]10[/SUB] (10μg/day for 10days), and/or infected with influenza (A/Mem/1/71) virus. Inflammation (cells, IL-6, IFN-γ) was measured in bronchoalveolar lavage. Lung mechanics were measured using the forced oscillation technique. Geogenic PM[SUB]10[/SUB] induced lung inflammation (neutrophils, macrophages) with additive effects in mice also infected with influenza. PM[SUB]10[/SUB] also modified the influenza-induced IL-6 and IFN-γ responses. Geogenic PM[SUB]10[/SUB] increased airway resistance, and increased hysteresivity in those exposed to both insults. Viral titres were significantly higher after PM[SUB]10[/SUB] exposure. Iron concentration was inversely associated with IFN-γ and positively associated with viral titre and hysteresivity. Geogenic PM[SUB]10[/SUB] exposure increases inflammation, impairs lung function and increases viral load, exacerbating the response to respiratory viral infection. Iron in the particles may be a driver of these responses. This has important implications for respiratory health in communities exposed to high geogenic PM[SUB]10[/SUB], such as those in arid environments.
Copyright ? 2015. Published by Elsevier B.V.
[h=4]KEYWORDS:[/h] Geogenic; Inflammation; Influenza; Iron; Lung function; Particle; Viral titre
PMID: 26172594 [PubMed - as supplied by publisher]