tetano
Editor, Senior Moderator
Vaccine. 2015 May 18. pii: S0264-410X(15)00634-9. doi: 10.1016/j.vaccine.2015.05.013. [Epub ahead of print]
[h=1]Guillain-Barr? syndrome and influenza vaccines: A meta-analysis.[/h] Mart?n Arias LH[SUP]1[/SUP], Sanz R[SUP]1[/SUP], S?inz M[SUP]1[/SUP], Trece?o C[SUP]1[/SUP], Carvajal A[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Cases of Guillain-Barr? syndrome (GBS) have been occasionally associated with influenza vaccines; this possible risk, even if rare, is a matter of much concern. To learn the strength of this association, a systematic review and a meta-analysis have been conducted; for the purpose, controlled observational studies addressing the risk of GBS associated with different influenza vaccines were sought. We finally selected 39 studies of interest published between 1981 and 2014 (seasonal influenza vaccines, 22; pandemic influenza vaccines, 16; both vaccines simultaneously administered, 1); funnel plot did not identify publication bias. At the association between any influenza vaccine - whether seasonal or pandemic - with GBS, the overall risk estimate was 1.41 (95%CI, 1.20-1.66); pandemic vaccines presented a slightly, though non significant, higher risk (RR=1.84; 95%CI, 1.36-2.50) compared to seasonal vaccines (RR=1.22; 95%CI, 1.01-1.48). Pandemic adjuvanted vaccines were not found to be related to a higher risk compared to non-adjuvanted vaccines. The results of the present meta-analysis point to a small but statistically significant association between influenza vaccines, particularly the pandemic ones, and GBS, which is consistent with current explanations upon possible mechanisms for this condition to appear.
Copyright ? 2015. Published by Elsevier Ltd.
[h=4]KEYWORDS:[/h] Guillain?Barr? syndrome; Influenza vaccines; Meta-analysis
PMID: 25999283 [PubMed - as supplied by publisher]
[h=1]Guillain-Barr? syndrome and influenza vaccines: A meta-analysis.[/h] Mart?n Arias LH[SUP]1[/SUP], Sanz R[SUP]1[/SUP], S?inz M[SUP]1[/SUP], Trece?o C[SUP]1[/SUP], Carvajal A[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Cases of Guillain-Barr? syndrome (GBS) have been occasionally associated with influenza vaccines; this possible risk, even if rare, is a matter of much concern. To learn the strength of this association, a systematic review and a meta-analysis have been conducted; for the purpose, controlled observational studies addressing the risk of GBS associated with different influenza vaccines were sought. We finally selected 39 studies of interest published between 1981 and 2014 (seasonal influenza vaccines, 22; pandemic influenza vaccines, 16; both vaccines simultaneously administered, 1); funnel plot did not identify publication bias. At the association between any influenza vaccine - whether seasonal or pandemic - with GBS, the overall risk estimate was 1.41 (95%CI, 1.20-1.66); pandemic vaccines presented a slightly, though non significant, higher risk (RR=1.84; 95%CI, 1.36-2.50) compared to seasonal vaccines (RR=1.22; 95%CI, 1.01-1.48). Pandemic adjuvanted vaccines were not found to be related to a higher risk compared to non-adjuvanted vaccines. The results of the present meta-analysis point to a small but statistically significant association between influenza vaccines, particularly the pandemic ones, and GBS, which is consistent with current explanations upon possible mechanisms for this condition to appear.
Copyright ? 2015. Published by Elsevier Ltd.
[h=4]KEYWORDS:[/h] Guillain?Barr? syndrome; Influenza vaccines; Meta-analysis
PMID: 25999283 [PubMed - as supplied by publisher]