tetano
Editor, Senior Moderator
J Infect Dis. 2012 Jul 20. [Epub ahead of print]
H5N1 Virus Causes Significant Perturbations in Host Proteome Very Early in Influenza Virus-Infected Primary Human Monocyte-Derived Macrophages.
Cheung CY, Chan EY, Krasnoselsky A, Purdy D, Navare AT, Bryan JT, Leung CK, Hui KP, Peiris JS, Katze MG.
Source
Centre of Influenza Research & School of Public Health, University of Hong Kong.
Abstract
H5N1 influenza viruses, which cause disease in humans, have unusually high pathogenicity. The temporal response of primary human monocyte-derived macrophages infected with highly pathogenic H5N1 and seasonal H1N1 influenza viruses was evaluated using mass spectrometry-based quantitative proteomic profiling. This was done in order to demonstrate significant perturbation of the host proteome upon viral infection, as early as 1 hour after infection. This early host response distinguished H5N1 infection from H1N1 infection, the latter inducing less of a response. The most pronounced effect was observed on the translational machinery, suggesting that H5N1 might gain advantage in replication by using the cell protein synthesis machinery early in the infection.
PMID:
22822004
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22822004
H5N1 Virus Causes Significant Perturbations in Host Proteome Very Early in Influenza Virus-Infected Primary Human Monocyte-Derived Macrophages.
Cheung CY, Chan EY, Krasnoselsky A, Purdy D, Navare AT, Bryan JT, Leung CK, Hui KP, Peiris JS, Katze MG.
Source
Centre of Influenza Research & School of Public Health, University of Hong Kong.
Abstract
H5N1 influenza viruses, which cause disease in humans, have unusually high pathogenicity. The temporal response of primary human monocyte-derived macrophages infected with highly pathogenic H5N1 and seasonal H1N1 influenza viruses was evaluated using mass spectrometry-based quantitative proteomic profiling. This was done in order to demonstrate significant perturbation of the host proteome upon viral infection, as early as 1 hour after infection. This early host response distinguished H5N1 infection from H1N1 infection, the latter inducing less of a response. The most pronounced effect was observed on the translational machinery, suggesting that H5N1 might gain advantage in replication by using the cell protein synthesis machinery early in the infection.
PMID:
22822004
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22822004