tetano
Editor, Senior Moderator
Avian Pathol. 2018 Jul 9:1-51. doi: 10.1080/03079457.2018.1492087. [Epub ahead of print]
[h=1]Highly pathogenic avian influenza A/H5N1 Clade 2.3.2.1c virus in poultry in Cameroon, 2016-2017.[/h] Wade A[SUP]1,[/SUP][SUP]2[/SUP], Ta?ga[SUP]2[/SUP], Fouda MA[SUP]3[/SUP], MaiMoussa A[SUP]4[/SUP], Jean Marc FK[SUP]2[/SUP], Njouom R[SUP]5[/SUP], Vernet MA[SUP]5[/SUP], Djonwe G[SUP]2[/SUP], Mballa E[SUP]3[/SUP], Kazi JP[SUP]1[/SUP], Nenkam R[SUP]1[/SUP], Poueme Namegni R[SUP]1[/SUP], Bamanga H[SUP]1[/SUP], Casimir NKM[SUP]2[/SUP], Lebreton M[SUP]6[/SUP], Nwobegahay J[SUP]7[/SUP], Fusaro A[SUP]8[/SUP], Zecchin B[SUP]8[/SUP], Milani A[SUP]8[/SUP], Gaston M[SUP]2[/SUP], Chepnda VR[SUP]9[/SUP], Dickmu Jumbo S[SUP]1[/SUP], Souley A[SUP]1[/SUP], Aboubakar Y[SUP]1[/SUP], Fotso Kamnga Z[SUP]2[/SUP], Couo K[SUP]2[/SUP], Atkam H[SUP]2[/SUP], Dauphin G[SUP]10[/SUP], Wiersma L[SUP]10[/SUP], Bebay C[SUP]10,[/SUP][SUP]11[/SUP], Nzietchueng S[SUP]12[/SUP], Vincent T[SUP]13[/SUP], Biaou C[SUP]10[/SUP], Mbacham W[SUP]14[/SUP], Monne I[SUP]8[/SUP], Cattoli G[SUP]15[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] In May 2016, highly pathogenic avian influenza virus (HPAIV) of the subtype A/H5N1 was detected in Cameroon in an industrial poultry farm at Mvog-Betsi, Yaounde (Centre region), with a recorded sudden increase of deaths among chickens, and an overall mortality rate of 75%. The virus spread further and caused new outbreaks in some parts of the country. In total, 21 outbreaks were confirmed from May 2016 to March 2017 (6 in the Centre, 6 in the West, 8 in the South and 1 in the Adamaoua regions). This resulted in an estimated total loss of 138,252 birds (44,451 death due to infection and 93,801 stamped out). Only domestic birds (chicken, ducks and geese) were affected both in farms as well as in poultry markets. The outbreaks occurred in three waves, the first from May-June 2016, the second in September 2016 and last wave in March 2017. The topology of the phylogeny based on the HA gene segment indicated that the causative H5N1 viruses fall within the genetic clade 2.3.2.1c, sharing a same group with the A/H5N1 viruses collected in Niger in 2015 and 2016. More importantly, the gene constellation of four representative viruses showed evidence of H5N1/H9N2 intra-clade reassortment. Additional epidemiological and genetic data from affected countries in West Africa are needed to better trace the origin, spread and evolution of A/H5N1 in Cameroon.
[h=4]KEYWORDS:[/h] Cameroon; HPAI-H5N1; full genome; intra-clade reassortment; outbreaks
PMID: 29985640 DOI: 10.1080/03079457.2018.1492087
[h=1]Highly pathogenic avian influenza A/H5N1 Clade 2.3.2.1c virus in poultry in Cameroon, 2016-2017.[/h] Wade A[SUP]1,[/SUP][SUP]2[/SUP], Ta?ga[SUP]2[/SUP], Fouda MA[SUP]3[/SUP], MaiMoussa A[SUP]4[/SUP], Jean Marc FK[SUP]2[/SUP], Njouom R[SUP]5[/SUP], Vernet MA[SUP]5[/SUP], Djonwe G[SUP]2[/SUP], Mballa E[SUP]3[/SUP], Kazi JP[SUP]1[/SUP], Nenkam R[SUP]1[/SUP], Poueme Namegni R[SUP]1[/SUP], Bamanga H[SUP]1[/SUP], Casimir NKM[SUP]2[/SUP], Lebreton M[SUP]6[/SUP], Nwobegahay J[SUP]7[/SUP], Fusaro A[SUP]8[/SUP], Zecchin B[SUP]8[/SUP], Milani A[SUP]8[/SUP], Gaston M[SUP]2[/SUP], Chepnda VR[SUP]9[/SUP], Dickmu Jumbo S[SUP]1[/SUP], Souley A[SUP]1[/SUP], Aboubakar Y[SUP]1[/SUP], Fotso Kamnga Z[SUP]2[/SUP], Couo K[SUP]2[/SUP], Atkam H[SUP]2[/SUP], Dauphin G[SUP]10[/SUP], Wiersma L[SUP]10[/SUP], Bebay C[SUP]10,[/SUP][SUP]11[/SUP], Nzietchueng S[SUP]12[/SUP], Vincent T[SUP]13[/SUP], Biaou C[SUP]10[/SUP], Mbacham W[SUP]14[/SUP], Monne I[SUP]8[/SUP], Cattoli G[SUP]15[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] In May 2016, highly pathogenic avian influenza virus (HPAIV) of the subtype A/H5N1 was detected in Cameroon in an industrial poultry farm at Mvog-Betsi, Yaounde (Centre region), with a recorded sudden increase of deaths among chickens, and an overall mortality rate of 75%. The virus spread further and caused new outbreaks in some parts of the country. In total, 21 outbreaks were confirmed from May 2016 to March 2017 (6 in the Centre, 6 in the West, 8 in the South and 1 in the Adamaoua regions). This resulted in an estimated total loss of 138,252 birds (44,451 death due to infection and 93,801 stamped out). Only domestic birds (chicken, ducks and geese) were affected both in farms as well as in poultry markets. The outbreaks occurred in three waves, the first from May-June 2016, the second in September 2016 and last wave in March 2017. The topology of the phylogeny based on the HA gene segment indicated that the causative H5N1 viruses fall within the genetic clade 2.3.2.1c, sharing a same group with the A/H5N1 viruses collected in Niger in 2015 and 2016. More importantly, the gene constellation of four representative viruses showed evidence of H5N1/H9N2 intra-clade reassortment. Additional epidemiological and genetic data from affected countries in West Africa are needed to better trace the origin, spread and evolution of A/H5N1 in Cameroon.
[h=4]KEYWORDS:[/h] Cameroon; HPAI-H5N1; full genome; intra-clade reassortment; outbreaks
PMID: 29985640 DOI: 10.1080/03079457.2018.1492087