tetano
Editor, Senior Moderator
Hum Immunol
. 2025 Feb 10;86(2):111261.
doi: 10.1016/j.humimm.2025.111261. Online ahead of print. Association of IL10 gene SNVs rs1800896 (A>G), rs1800871 (C>T), rs1800872 (C>A) and haplotypes with COVID-19 severity and outcome in the Brazilian population
Janaina Nicolau de Oliveira[SUP] 1 [/SUP], Caroline Yukari Motoori Fernandes[SUP] 1 [/SUP], Sara Mataroli de Godoy[SUP] 2 [/SUP], Wilson Frantine-Silva[SUP] 2 [/SUP], Pedro Luis Candido de Souza Cassela[SUP] 3 [/SUP], Guilherme Lerner Trigo[SUP] 3 [/SUP], Marcell Alysson Batisti Lozovoy[SUP] 3 [/SUP], Zuleica Naomi Tano[SUP] 4 [/SUP], Andrea Name Colado Simão[SUP] 3 [/SUP], Karen Brajão de Oliveira[SUP] 5 [/SUP]
Affiliations
Background: Elevated concentrations of IL-10 have been detected in coronavirus disease (COVID-19) patients and are a possible disease severity marker. Single nucleotide variants (SNVs) and their haplotypes can be associated with differences in IL-10 levels and with viral disease susceptibility.
Aim: Evaluate the associations of SNVs and their haplotypes in Brazilian patients with COVID-19 severity and outcome.
Methods: In this cross-sectional and case-control study, the patients were selected from the University Hospital of State University of Londrina (HU-UEL) (n = 367) and were subdivided into mild (n = 165), moderate (n = 72) and severe (n = 130) groups. The DNA samples of the participants were subjected to real-time PCR for the detection of rs1800896 (A>G), rs1800871 (C>T) and rs1800872 (C>A) genotypes. The haplotypes were inferred with PHASE v2.1.1.
Results: The severe cases of COVID-19 were independently associated with the GG genotype (rs1800896) (P = 0.038, OR 2.522, 95 % CI 1.053-6.038) as well as with the GCC haplotype in homozygosity (P = 0.037, OR 2.767, 95 % CI 1.065-7.191).
Conclusion: These results showed that the GG genotype of rs1800896 or the GCC haplotype are associated with COVID-19 severity in Brazilian patients.
Keywords: Interleukin-10; Polymorphism; Rs1800871 (−819 C > T); Rs1800872 (−592 C > A); Rs1800896 (−1082 A > G); Severe acute respiratory syndrome-related coronavirus; Single nucleotide.
. 2025 Feb 10;86(2):111261.
doi: 10.1016/j.humimm.2025.111261. Online ahead of print. Association of IL10 gene SNVs rs1800896 (A>G), rs1800871 (C>T), rs1800872 (C>A) and haplotypes with COVID-19 severity and outcome in the Brazilian population
Janaina Nicolau de Oliveira[SUP] 1 [/SUP], Caroline Yukari Motoori Fernandes[SUP] 1 [/SUP], Sara Mataroli de Godoy[SUP] 2 [/SUP], Wilson Frantine-Silva[SUP] 2 [/SUP], Pedro Luis Candido de Souza Cassela[SUP] 3 [/SUP], Guilherme Lerner Trigo[SUP] 3 [/SUP], Marcell Alysson Batisti Lozovoy[SUP] 3 [/SUP], Zuleica Naomi Tano[SUP] 4 [/SUP], Andrea Name Colado Simão[SUP] 3 [/SUP], Karen Brajão de Oliveira[SUP] 5 [/SUP]
Affiliations
- PMID: 39933261
- DOI: 10.1016/j.humimm.2025.111261
Background: Elevated concentrations of IL-10 have been detected in coronavirus disease (COVID-19) patients and are a possible disease severity marker. Single nucleotide variants (SNVs) and their haplotypes can be associated with differences in IL-10 levels and with viral disease susceptibility.
Aim: Evaluate the associations of SNVs and their haplotypes in Brazilian patients with COVID-19 severity and outcome.
Methods: In this cross-sectional and case-control study, the patients were selected from the University Hospital of State University of Londrina (HU-UEL) (n = 367) and were subdivided into mild (n = 165), moderate (n = 72) and severe (n = 130) groups. The DNA samples of the participants were subjected to real-time PCR for the detection of rs1800896 (A>G), rs1800871 (C>T) and rs1800872 (C>A) genotypes. The haplotypes were inferred with PHASE v2.1.1.
Results: The severe cases of COVID-19 were independently associated with the GG genotype (rs1800896) (P = 0.038, OR 2.522, 95 % CI 1.053-6.038) as well as with the GCC haplotype in homozygosity (P = 0.037, OR 2.767, 95 % CI 1.065-7.191).
Conclusion: These results showed that the GG genotype of rs1800896 or the GCC haplotype are associated with COVID-19 severity in Brazilian patients.
Keywords: Interleukin-10; Polymorphism; Rs1800871 (−819 C > T); Rs1800872 (−592 C > A); Rs1800896 (−1082 A > G); Severe acute respiratory syndrome-related coronavirus; Single nucleotide.