tetano
Editor, Senior Moderator
Hum Immunol
. 2020 Sep 16;S0198-8859(20)30390-6.
doi: 10.1016/j.humimm.2020.08.006. Online ahead of print.
Characteristics of immune cells and cytokines in patients with coronavirus disease 2019 in Guangzhou, China
Xing Chen[SUP] 1 [/SUP], Jide Huang[SUP] 1 [/SUP], Ying Huang[SUP] 1 [/SUP], Jiabin Chen[SUP] 1 [/SUP], Yingyi Huang[SUP] 1 [/SUP], Xiaowen Jiang[SUP] 1 [/SUP], Yaling Shi[SUP] 2 [/SUP]
Affiliations
Abstract
To discover immune factors that can predict the progression of COVID-19, we evaluated circulating immune cells and plasma cytokines in COVID-19 patients. We found that T cells, including CD4[SUP]+[/SUP] T cells and CD8[SUP]+[/SUP] T cells, were significantly decreased in severe COVID-19 symptoms but not in mild symptoms, in comparison with healthy people. T cells remained at a low level after recovery from severe COVID-19. CD4[SUP]+[/SUP]CD25[SUP]+[/SUP]CD127[SUP]low[/SUP] Treg-enriched cells were significantly increased in either mild or severe COVID-19 patients, regardless of recovery or not. Moreover, in either mild or severe COVID-19 patients, Treg-enriched cells up-regulated CD25 and down-regulated CD127. After recovery, CD25 was partially down-regulated but still higher than the normal level, while CD127 returned to the normal level in mild patients but not severe patients. B cells were decreased in mild patients and further decreased in severe patients, and remained low after recovery. NK cells were decreased only in severe COVID-19, with a tendency to return to the normal level after recovery. Plasma IL-6 and IL-10 were both elevated in severe patients but not in mild patients. After recovery, IL-6 remained higher than its normal level, while IL-10 returned to the normal level. Binary logistic regression analysis indicated that CD4[SUP]+[/SUP] T cells, B cells, IL-6, and IL-10 were significantly associated with COVID-19 severity. Therefore, these parameters are indicators of COVID-19 severity. Dynamic monitoring of these parameters would benefit therapy planning and prognosis evaluation.
Keywords: COVID-19; Cytokines; Immune cells; Inflammation; SARS-CoV-2.
. 2020 Sep 16;S0198-8859(20)30390-6.
doi: 10.1016/j.humimm.2020.08.006. Online ahead of print.
Characteristics of immune cells and cytokines in patients with coronavirus disease 2019 in Guangzhou, China
Xing Chen[SUP] 1 [/SUP], Jide Huang[SUP] 1 [/SUP], Ying Huang[SUP] 1 [/SUP], Jiabin Chen[SUP] 1 [/SUP], Yingyi Huang[SUP] 1 [/SUP], Xiaowen Jiang[SUP] 1 [/SUP], Yaling Shi[SUP] 2 [/SUP]
Affiliations
- PMID: 32950268
- DOI: 10.1016/j.humimm.2020.08.006
Abstract
To discover immune factors that can predict the progression of COVID-19, we evaluated circulating immune cells and plasma cytokines in COVID-19 patients. We found that T cells, including CD4[SUP]+[/SUP] T cells and CD8[SUP]+[/SUP] T cells, were significantly decreased in severe COVID-19 symptoms but not in mild symptoms, in comparison with healthy people. T cells remained at a low level after recovery from severe COVID-19. CD4[SUP]+[/SUP]CD25[SUP]+[/SUP]CD127[SUP]low[/SUP] Treg-enriched cells were significantly increased in either mild or severe COVID-19 patients, regardless of recovery or not. Moreover, in either mild or severe COVID-19 patients, Treg-enriched cells up-regulated CD25 and down-regulated CD127. After recovery, CD25 was partially down-regulated but still higher than the normal level, while CD127 returned to the normal level in mild patients but not severe patients. B cells were decreased in mild patients and further decreased in severe patients, and remained low after recovery. NK cells were decreased only in severe COVID-19, with a tendency to return to the normal level after recovery. Plasma IL-6 and IL-10 were both elevated in severe patients but not in mild patients. After recovery, IL-6 remained higher than its normal level, while IL-10 returned to the normal level. Binary logistic regression analysis indicated that CD4[SUP]+[/SUP] T cells, B cells, IL-6, and IL-10 were significantly associated with COVID-19 severity. Therefore, these parameters are indicators of COVID-19 severity. Dynamic monitoring of these parameters would benefit therapy planning and prognosis evaluation.
Keywords: COVID-19; Cytokines; Immune cells; Inflammation; SARS-CoV-2.