Hypothalamic abnormalities and Parkinsonism associated with H1N1 influenza infection
Garc?a-Ramos
Department of Neurology, Instituto Nacional de Ciencias M?dicas y Nutrici?n Salvador Zubir?n, M?xico D.F., M?xico
Journal of Neuroinflammation 2010, 7:47doi:10.1186/1742-2094-7-47
The electronic version of this article is the complete one and can be found online at:
http://www.jneuroinflammation.com/content/7/1/47
Received: 30 June 2010
Accepted: 17 August 2010
Published: 17 August 2010
? 2010 Gonz?lez-Duarte et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Objective
To describe a case of a young adult with severe H1N1 influenza illness associated with hypothalamic abnormalities and post-influenza parkinsonism.
Design
Case report.
Patient
A 22-year-old woman with H1N1 influenza infection developed encephalopathy followed by diverse hypothalamic dysfunction manifestations, sleeplessness, and persistent parkinsonian features.
Results
CSF analysis, brain imaging and EEG ruled out hypoxic brain injury or other illnesses.
Conclusions
A number of viruses have been associated with both acute and chronic parkinsonism. A link between parkinsonism and influenza viruses is somewhat controversial. This is the first reported case of parkinsonism following an H1N1 influenza infection.
