tetano
Editor, Senior Moderator
Blood. 2014 Apr 10. [Epub ahead of print]
Id2 represses E2A-mediated activation of IL-10 expression in T cells.
Masson F1, Ghisi M, Groom JR, Kallies A, Seillet C, Johnstone R, Nutt SL, Belz GT.
Author information
Abstract
Interleukin (IL)-10 is a key immunoregulatory cytokine that functions to prevent inflammatory and autoimmune diseases. Despite the critical role for IL-10 produced by effector CD8+ T cells during pathogen infection and autoimmunity, the mechanisms regulating its production are poorly understood. We show that loss of the Inhibitor of DNA binding (Id) 2 in T cells resulted in aberrant IL-10 expression in vitro and in vivo during influenza virus infection and in a model of acute graft vs. host disease (GVHD). Furthermore, IL-10 over-production substantially reduced the immunopathology associated with GVHD. We demonstrate that Id2 acts to repress the E2A-mediated trans-activation of the Il10 locus. Collectively, our findings uncover a key regulatory role of Id2 during effector T cell differentiation necessary to limit IL-10 production by activated T cells and minimize their suppressive activity during the effector phase of disease control.
PMID:
24723679
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24723679
Id2 represses E2A-mediated activation of IL-10 expression in T cells.
Masson F1, Ghisi M, Groom JR, Kallies A, Seillet C, Johnstone R, Nutt SL, Belz GT.
Author information
Abstract
Interleukin (IL)-10 is a key immunoregulatory cytokine that functions to prevent inflammatory and autoimmune diseases. Despite the critical role for IL-10 produced by effector CD8+ T cells during pathogen infection and autoimmunity, the mechanisms regulating its production are poorly understood. We show that loss of the Inhibitor of DNA binding (Id) 2 in T cells resulted in aberrant IL-10 expression in vitro and in vivo during influenza virus infection and in a model of acute graft vs. host disease (GVHD). Furthermore, IL-10 over-production substantially reduced the immunopathology associated with GVHD. We demonstrate that Id2 acts to repress the E2A-mediated trans-activation of the Il10 locus. Collectively, our findings uncover a key regulatory role of Id2 during effector T cell differentiation necessary to limit IL-10 production by activated T cells and minimize their suppressive activity during the effector phase of disease control.
PMID:
24723679
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24723679