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http://www.elmundo.es/elmundo/2011/05/09/andalucia_sevilla/1304968397.html
Spanish to English translation
Identified two genes involved in the onset of multiple sclerosis
Europa Press | Sevilla
Updated Monday 09/05/2011 21:13 hours
A research team at the Hospital Virgen Macarena in Seville, led by neurologist Guillermo Izquierdo , has managed to identify two genes that are involved in the development of Multiple Sclerosis (MS), a neurodegenerative disease that occurs when the myelin (a substance that lines nerve fibers) is damaged.
In fact, it is believed that there is a genetic predisposition for developing this disease, although in combination with a foreign agent that subsequently triggers the body's own immune response that damages the myelin.
Izquierdo has detailed his research group has managed to find now, through a study that involved 300 patients have this condition, "two genes are clearly involved in the development of this disease and a third gene that may be, too ".
Advances
It has also highlighted that the two genes related to MS now "have to do with immunity, that is, we're talking about genes that are very logical that they are involved in MS." To this end, the company has received biomedical Seville Neocodex , which has one of the most comprehensive platform of genomic research in Spain.
"With the support of Neocodex we have to perform a GWAS, ie a crawl or complete genomic mapping of all patients who have a disease and compared it with genes from another population (healthy)", detailed the specialist the field of MS, who has clarified that "although this and so have many other researchers before, "the difference now is that" our 300 patients are very well phenotyped , ie, we know who have MS and therefore have been more profitable in the study. "
"These results as good answer probably because we used very clear cases of patients with MS and we have used a bookmark that is very important and specific about the disease, as is the presence of oligoclonal bands in cerebrospinal fluid , "stressed .
The next planned study
As he explained to Europa Press Left, the more genes are known to be involved in the development of MS will be closer to developing a genetic test to predict disease even before getting it. "
"It is almost certain that MS is genetically inherited by the association of different genes that match a patient, hence at any given time algorithm can find a study to analyze not a gene or two, but the 200, 300 or we found found that allow us to predict a possibility of more than 90% if a person will suffer from MS or not. "
Izquierdo has also advanced with plans to conduct another study of the type also with 300 other patients, but have yet to find financing, "because they are expensive investigations . " In fact, emphasized that the study has now decode these two genes "have had to invest 200,000 euros, which we paid we were awarded two grants to public institutions."
Izquierdo was confident that within five years, and especially with the development of studies being conducted in the U.S., may have such genetic testing. "That is, a chip that a doctor can predict what percentage of a person suffering from a MS throughout its life, even what you might say at birth," he underlined.
Spanish to English translation
Identified two genes involved in the onset of multiple sclerosis
Europa Press | Sevilla
Updated Monday 09/05/2011 21:13 hours
A research team at the Hospital Virgen Macarena in Seville, led by neurologist Guillermo Izquierdo , has managed to identify two genes that are involved in the development of Multiple Sclerosis (MS), a neurodegenerative disease that occurs when the myelin (a substance that lines nerve fibers) is damaged.
In fact, it is believed that there is a genetic predisposition for developing this disease, although in combination with a foreign agent that subsequently triggers the body's own immune response that damages the myelin.
Izquierdo has detailed his research group has managed to find now, through a study that involved 300 patients have this condition, "two genes are clearly involved in the development of this disease and a third gene that may be, too ".
Advances
It has also highlighted that the two genes related to MS now "have to do with immunity, that is, we're talking about genes that are very logical that they are involved in MS." To this end, the company has received biomedical Seville Neocodex , which has one of the most comprehensive platform of genomic research in Spain.
"With the support of Neocodex we have to perform a GWAS, ie a crawl or complete genomic mapping of all patients who have a disease and compared it with genes from another population (healthy)", detailed the specialist the field of MS, who has clarified that "although this and so have many other researchers before, "the difference now is that" our 300 patients are very well phenotyped , ie, we know who have MS and therefore have been more profitable in the study. "
"These results as good answer probably because we used very clear cases of patients with MS and we have used a bookmark that is very important and specific about the disease, as is the presence of oligoclonal bands in cerebrospinal fluid , "stressed .
The next planned study
As he explained to Europa Press Left, the more genes are known to be involved in the development of MS will be closer to developing a genetic test to predict disease even before getting it. "
"It is almost certain that MS is genetically inherited by the association of different genes that match a patient, hence at any given time algorithm can find a study to analyze not a gene or two, but the 200, 300 or we found found that allow us to predict a possibility of more than 90% if a person will suffer from MS or not. "
Izquierdo has also advanced with plans to conduct another study of the type also with 300 other patients, but have yet to find financing, "because they are expensive investigations . " In fact, emphasized that the study has now decode these two genes "have had to invest 200,000 euros, which we paid we were awarded two grants to public institutions."
Izquierdo was confident that within five years, and especially with the development of studies being conducted in the U.S., may have such genetic testing. "That is, a chip that a doctor can predict what percentage of a person suffering from a MS throughout its life, even what you might say at birth," he underlined.