tetano
Editor, Senior Moderator
Immunity
. 2024 Mar 8:S1074-7613(24)00092-X.
doi: 10.1016/j.immuni.2024.02.016. Online ahead of print. Persistent immune imprinting occurs after vaccination with the COVID-19 XBB.1.5 mRNA booster in humans
M Alejandra Tortorici[SUP] 1 [/SUP], Amin Addetia[SUP] 1 [/SUP], Albert J Seo[SUP] 1 [/SUP], Jack Brown[SUP] 1 [/SUP], Kaiti Sprouse[SUP] 1 [/SUP], Jenni Logue[SUP] 2 [/SUP], Erica Clark[SUP] 2 [/SUP], Nicholas Franko[SUP] 2 [/SUP], Helen Chu[SUP] 2 [/SUP], David Veesler[SUP] 3 [/SUP]
Affiliations
Immune imprinting describes how the first exposure to a virus shapes immunological outcomes of subsequent exposures to antigenically related strains. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Omicron breakthrough infections and bivalent COVID-19 vaccination primarily recall cross-reactive memory B cells induced by prior Wuhan-Hu-1 spike mRNA vaccination rather than priming Omicron-specific naive B cells. These findings indicate that immune imprinting occurs after repeated Wuhan-Hu-1 spike exposures, but whether it can be overcome remains unclear. To understand the persistence of immune imprinting, we investigated memory and plasma antibody responses after administration of the updated XBB.1.5 COVID-19 mRNA vaccine booster. We showed that the XBB.1.5 booster elicited neutralizing antibody responses against current variants that were dominated by recall of pre-existing memory B cells previously induced by the Wuhan-Hu-1 spike. Therefore, immune imprinting persists after multiple exposures to Omicron spikes through vaccination and infection, including post XBB.1.5 booster vaccination, which will need to be considered to guide future vaccination.
Keywords: COVID-19 mRNA vaccines; SARS-CoV-2; SARS-CoV-2 variants; coronaviruses; depletion assays; immune imprinting; memory B cells; neutralizing antibodies; spike glycoprotein.
. 2024 Mar 8:S1074-7613(24)00092-X.
doi: 10.1016/j.immuni.2024.02.016. Online ahead of print. Persistent immune imprinting occurs after vaccination with the COVID-19 XBB.1.5 mRNA booster in humans
M Alejandra Tortorici[SUP] 1 [/SUP], Amin Addetia[SUP] 1 [/SUP], Albert J Seo[SUP] 1 [/SUP], Jack Brown[SUP] 1 [/SUP], Kaiti Sprouse[SUP] 1 [/SUP], Jenni Logue[SUP] 2 [/SUP], Erica Clark[SUP] 2 [/SUP], Nicholas Franko[SUP] 2 [/SUP], Helen Chu[SUP] 2 [/SUP], David Veesler[SUP] 3 [/SUP]
Affiliations
- PMID: 38490197
- DOI: 10.1016/j.immuni.2024.02.016
Immune imprinting describes how the first exposure to a virus shapes immunological outcomes of subsequent exposures to antigenically related strains. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Omicron breakthrough infections and bivalent COVID-19 vaccination primarily recall cross-reactive memory B cells induced by prior Wuhan-Hu-1 spike mRNA vaccination rather than priming Omicron-specific naive B cells. These findings indicate that immune imprinting occurs after repeated Wuhan-Hu-1 spike exposures, but whether it can be overcome remains unclear. To understand the persistence of immune imprinting, we investigated memory and plasma antibody responses after administration of the updated XBB.1.5 COVID-19 mRNA vaccine booster. We showed that the XBB.1.5 booster elicited neutralizing antibody responses against current variants that were dominated by recall of pre-existing memory B cells previously induced by the Wuhan-Hu-1 spike. Therefore, immune imprinting persists after multiple exposures to Omicron spikes through vaccination and infection, including post XBB.1.5 booster vaccination, which will need to be considered to guide future vaccination.
Keywords: COVID-19 mRNA vaccines; SARS-CoV-2; SARS-CoV-2 variants; coronaviruses; depletion assays; immune imprinting; memory B cells; neutralizing antibodies; spike glycoprotein.