tetano
Editor, Senior Moderator
Biochim Biophys Acta. 2014 May 31. pii: S1570-9639(14)00148-4. doi: 10.1016/j.bbapap.2014.05.010. [Epub ahead of print]
Immunogen Design for HIV-1 and Influenza.
Rathore U1, Kesavardhana S1, Mallajosyula VV1, Varadarajan R2.
Author information
Abstract
Vaccines provide the most cost effective defence against pathogens. Although vaccines have been designed for a number of viral diseases, a vaccine against HIV-1 still remains elusive. In contrast, while there are excellent influenza vaccines, these need to be changed every few years because of antigenic drift and shift. The recent discovery of a large number of broadly neutralizing antibodies (bNAbs) and structural characterization of the conserved epitopes targeted by them presents an opportunity for structure based HIV-1 and influenza A vaccine design. We discuss strategies to design immunogens either targeting a particular antigenic region or focussing on native structure stabilization. This article is part of a Special Issue entitled: Recent advances in molecular engineering of antibody.
Copyright ? 2014. Published by Elsevier B.V.
KEYWORDS:
Glycosylation; Native trimer; Protein minimization; Stability; Vaccine
PMID:
24892211
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24892211
Immunogen Design for HIV-1 and Influenza.
Rathore U1, Kesavardhana S1, Mallajosyula VV1, Varadarajan R2.
Author information
Abstract
Vaccines provide the most cost effective defence against pathogens. Although vaccines have been designed for a number of viral diseases, a vaccine against HIV-1 still remains elusive. In contrast, while there are excellent influenza vaccines, these need to be changed every few years because of antigenic drift and shift. The recent discovery of a large number of broadly neutralizing antibodies (bNAbs) and structural characterization of the conserved epitopes targeted by them presents an opportunity for structure based HIV-1 and influenza A vaccine design. We discuss strategies to design immunogens either targeting a particular antigenic region or focussing on native structure stabilization. This article is part of a Special Issue entitled: Recent advances in molecular engineering of antibody.
Copyright ? 2014. Published by Elsevier B.V.
KEYWORDS:
Glycosylation; Native trimer; Protein minimization; Stability; Vaccine
PMID:
24892211
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24892211