tetano
Editor, Senior Moderator
J Trop Pediatr. 2018 Dec 24. doi: 10.1093/tropej/fmy075. [Epub ahead of print]
[h=1]Impact of H1N1 Influenza Vaccination on Child Morbidity in Guinea-Bissau.[/h] Hansen OB MD[SUP]1,[/SUP][SUP]2[/SUP], Rodrigues A PhD[SUP]1[/SUP], Martins C PhD[SUP]1[/SUP], Rieckmann A PhD[SUP]2[/SUP], Benn CS DMSc[SUP]2,[/SUP][SUP]3[/SUP], Aaby P DMSc[SUP]1,[/SUP][SUP]2[/SUP], Fisker AB PhD[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]Background:[/h] In addition to vaccines' specific effects, vaccines may have non-specific effects (NSEs) altering the susceptibility to unrelated infections. Non-live vaccines have been associated with negative NSEs. In 2010, a campaign with the non-live H1N1-influenza vaccine targeted children 6-59 months in Guinea-Bissau.
[h=4]Methods:[/h] Bandim Health Project runs a health and demographic surveillance system site in Guinea-Bissau. Using a Cox proportional hazards model, we compared all-cause consultation rates after vs. before the campaign, stratified by participation status.
[h=4]Results:[/h] Among 10 290 children eligible for the campaign, 60% had participated, 18% had not and for 22% no information was obtained. After the H1N1 campaign, the consultation rates tended to decline more for participants [HR = 0.80 (95% confidence interval, CI: 0.75; 0.85)] than for non-participants [HR = 0.68 (95% CI: 0.58; 0.79)], p = 0.06 for same effect.
[h=4]Conclusion:[/h] The decline in the vaccinated group may have been smaller than the decline in the non-vaccinated group consistent with H1N1-vaccine increasing susceptibility to unrelated infections.
PMID: 30590828 DOI: 10.1093/tropej/fmy075
[h=1]Impact of H1N1 Influenza Vaccination on Child Morbidity in Guinea-Bissau.[/h] Hansen OB MD[SUP]1,[/SUP][SUP]2[/SUP], Rodrigues A PhD[SUP]1[/SUP], Martins C PhD[SUP]1[/SUP], Rieckmann A PhD[SUP]2[/SUP], Benn CS DMSc[SUP]2,[/SUP][SUP]3[/SUP], Aaby P DMSc[SUP]1,[/SUP][SUP]2[/SUP], Fisker AB PhD[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]Background:[/h] In addition to vaccines' specific effects, vaccines may have non-specific effects (NSEs) altering the susceptibility to unrelated infections. Non-live vaccines have been associated with negative NSEs. In 2010, a campaign with the non-live H1N1-influenza vaccine targeted children 6-59 months in Guinea-Bissau.
[h=4]Methods:[/h] Bandim Health Project runs a health and demographic surveillance system site in Guinea-Bissau. Using a Cox proportional hazards model, we compared all-cause consultation rates after vs. before the campaign, stratified by participation status.
[h=4]Results:[/h] Among 10 290 children eligible for the campaign, 60% had participated, 18% had not and for 22% no information was obtained. After the H1N1 campaign, the consultation rates tended to decline more for participants [HR = 0.80 (95% confidence interval, CI: 0.75; 0.85)] than for non-participants [HR = 0.68 (95% CI: 0.58; 0.79)], p = 0.06 for same effect.
[h=4]Conclusion:[/h] The decline in the vaccinated group may have been smaller than the decline in the non-vaccinated group consistent with H1N1-vaccine increasing susceptibility to unrelated infections.
PMID: 30590828 DOI: 10.1093/tropej/fmy075