tetano
Editor, Senior Moderator
In Vivo
. Sep-Oct 2021;35(5):2947-2949.
doi: 10.21873/invivo.12587.
Nine Cases of SARS-CoV-2-PCR-positive Samples Showed No Increase of Antibodies Against SARS-CoV-2
Takao Kitagawa[SUP] 1 [/SUP], Masanobu Kobayashi[SUP] 1 [/SUP], Tohru Ohta[SUP] 1 [/SUP], Masaru Terasaki[SUP] 1 [/SUP], Yoko Tsukamoto[SUP] 2 [/SUP], Rie Takai[SUP] 1 [/SUP], Reika Ishizumi[SUP] 2 [/SUP], Osamu Uehara[SUP] 1 [/SUP], Koji Nakagawa[SUP] 1 [/SUP], Kozo Akino[SUP] 1 [/SUP], Masahiro Asaka[SUP] 1 [/SUP], Yasuhiro Kuramitsu[SUP] 3 [/SUP]
Affiliations
Abstract
Background/aim: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been affecting Hokkaido, Japan since late February 2020 until present. The aim of this study was to report the relationship between anti-SARS-CoV-2 antibody-positive and SARS-CoV-2 PCR-positive cases by analyzing anti-SARS-CoV-2 antibodies (IgG and total-Ig).
Patients and methods: Serum samples were collected from care workers and nurses in two nursing homes and two hospitals which underwent virus outbreak. All people were confirmed to be SARS-CoV-2-positive by RT-qPCR and their sera was analyzed for anti-SARS-CoV-2 antibodies (IgG and total-Ig).
Results: Although 34 out of 43 samples (79.1%) showed enough amount of anti-SARS-CoV-2 antibodies, 9 RT-qPCR -positive samples (20.9%) showed absence of anti-SARS-CoV-2 antibodies in their sera.
Conclusion: The results that 20.9% of RT-qPCR-positive samples with SARS-CoV-2 showed absence of anti-SARS-CoV-2 antibodies provides a possibility that the innate immune reaction could eliminate the virus without activating adaptive immune reaction.
Keywords: COVID-19; SARS-Cov-2; antibodies; innate immunity.
. Sep-Oct 2021;35(5):2947-2949.
doi: 10.21873/invivo.12587.
Nine Cases of SARS-CoV-2-PCR-positive Samples Showed No Increase of Antibodies Against SARS-CoV-2
Takao Kitagawa[SUP] 1 [/SUP], Masanobu Kobayashi[SUP] 1 [/SUP], Tohru Ohta[SUP] 1 [/SUP], Masaru Terasaki[SUP] 1 [/SUP], Yoko Tsukamoto[SUP] 2 [/SUP], Rie Takai[SUP] 1 [/SUP], Reika Ishizumi[SUP] 2 [/SUP], Osamu Uehara[SUP] 1 [/SUP], Koji Nakagawa[SUP] 1 [/SUP], Kozo Akino[SUP] 1 [/SUP], Masahiro Asaka[SUP] 1 [/SUP], Yasuhiro Kuramitsu[SUP] 3 [/SUP]
Affiliations
- PMID: 34410992
- DOI: 10.21873/invivo.12587
Abstract
Background/aim: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been affecting Hokkaido, Japan since late February 2020 until present. The aim of this study was to report the relationship between anti-SARS-CoV-2 antibody-positive and SARS-CoV-2 PCR-positive cases by analyzing anti-SARS-CoV-2 antibodies (IgG and total-Ig).
Patients and methods: Serum samples were collected from care workers and nurses in two nursing homes and two hospitals which underwent virus outbreak. All people were confirmed to be SARS-CoV-2-positive by RT-qPCR and their sera was analyzed for anti-SARS-CoV-2 antibodies (IgG and total-Ig).
Results: Although 34 out of 43 samples (79.1%) showed enough amount of anti-SARS-CoV-2 antibodies, 9 RT-qPCR -positive samples (20.9%) showed absence of anti-SARS-CoV-2 antibodies in their sera.
Conclusion: The results that 20.9% of RT-qPCR-positive samples with SARS-CoV-2 showed absence of anti-SARS-CoV-2 antibodies provides a possibility that the innate immune reaction could eliminate the virus without activating adaptive immune reaction.
Keywords: COVID-19; SARS-Cov-2; antibodies; innate immunity.