tetano
Editor, Senior Moderator
Infect Dis (Lond)
. 2023 Jul 26;1-5.
doi: 10.1080/23744235.2023.2238077. Online ahead of print. Combination of two rare mutations in the SARS-CoV-2 M gene in patients with severe and prolonged COVID-19
Angelina Trifonova[SUP] 1 [/SUP], Atanas Syarov[SUP] 2 [/SUP], Svetlomir Takov[SUP] 3 [/SUP], Krassimir Angelov[SUP] 3 [/SUP], Radoslava Vazharova[SUP] 2 [/SUP], Velislava Terzieva[SUP] 1 [/SUP]
Affiliations
Background: The SARS-CoV-2 virus significantly changed our knowledge about coronaviruses. The interplay between SARS-CoV-2 and the human host, the infection ranges from asymptomatic to lethal, and differences in the degree of disease severity are important examples.
Methods: In this retrospective study, 24 nasopharyngeal swabs from 21 out of 457 patients with SARS-CoV-2 infection were analysed by whole-genome sequencing. The principal selection criteria were the duration of infection and disease severity.
Results: Two co-occurring rare mutations in the SARS-CoV-2 M gene were detected in six samples. Three of these samples were collected from an immunocompromised patient with fatal outcome, two from an immunocompetent patient, and one from a patient with severe disease and fatal outcome, all with a prolonged course of infection.
Conclusions: Although this interesting finding was demonstrated in a small number of patients, the results increase the knowledge regarding the significance of mutations in the M gene of SARS-CoV-2 in the context of persistent infection and viral escape mechanisms.
Keywords: COVID-19; M gene; SARS-CoV-2; mutation; prolonged infection.
. 2023 Jul 26;1-5.
doi: 10.1080/23744235.2023.2238077. Online ahead of print. Combination of two rare mutations in the SARS-CoV-2 M gene in patients with severe and prolonged COVID-19
Angelina Trifonova[SUP] 1 [/SUP], Atanas Syarov[SUP] 2 [/SUP], Svetlomir Takov[SUP] 3 [/SUP], Krassimir Angelov[SUP] 3 [/SUP], Radoslava Vazharova[SUP] 2 [/SUP], Velislava Terzieva[SUP] 1 [/SUP]
Affiliations
- PMID: 37493404
- DOI: 10.1080/23744235.2023.2238077
Background: The SARS-CoV-2 virus significantly changed our knowledge about coronaviruses. The interplay between SARS-CoV-2 and the human host, the infection ranges from asymptomatic to lethal, and differences in the degree of disease severity are important examples.
Methods: In this retrospective study, 24 nasopharyngeal swabs from 21 out of 457 patients with SARS-CoV-2 infection were analysed by whole-genome sequencing. The principal selection criteria were the duration of infection and disease severity.
Results: Two co-occurring rare mutations in the SARS-CoV-2 M gene were detected in six samples. Three of these samples were collected from an immunocompromised patient with fatal outcome, two from an immunocompetent patient, and one from a patient with severe disease and fatal outcome, all with a prolonged course of infection.
Conclusions: Although this interesting finding was demonstrated in a small number of patients, the results increase the knowledge regarding the significance of mutations in the M gene of SARS-CoV-2 in the context of persistent infection and viral escape mechanisms.
Keywords: COVID-19; M gene; SARS-CoV-2; mutation; prolonged infection.