tetano
Editor, Senior Moderator
Infect Dis (Lond)
. 2020 Nov 10;1-11.
doi: 10.1080/23744235.2020.1840623. Online ahead of print.
Comparison of the clinical characteristics and outcomes of hospitalized adult COVID-19 and influenza patients - a prospective observational study
Raija Auvinen[SUP] 1 2 [/SUP], Hanna Nohynek[SUP] 2 [/SUP], Ritva Syrj?nen[SUP] 3 [/SUP], Jukka Ollgren[SUP] 2 [/SUP], Tuija Kerttula[SUP] 4 [/SUP], Jarkko M?ntyl?[SUP] 5 [/SUP], Niina Ikonen[SUP] 6 [/SUP], Raisa Loginov[SUP] 7 [/SUP], Anu Haveri[SUP] 6 [/SUP], Satu Kurkela[SUP] 7 [/SUP], Kirsi Skogberg[SUP] 8 [/SUP]
Affiliations
Abstract
Background: We compared the clinical characteristics, findings, and outcomes of hospitalized patients with coronavirus disease 2019 (COVID-19) or influenza to detect relevant differences.
Methods: From December 2019 to April 2020, we recruited all eligible hospitalized adults with respiratory infection to a prospective observational study at a tertiary care hospital in Finland. Influenza and SARS-CoV-2 infections were confirmed by RT-PCR. Follow-up lasted for 3 months from admission.
Results: We included 61 patients, of whom 28 were COVID-19 and 33 influenza patients with median ages of 53 and 56 years. Majority of both COVID-19 and influenza patients were men (61% vs. 67%) and had at least one comorbidity (68% vs. 85%). Pulmonary diseases and current smoking were less common among COVID-19 than influenza patients (5 [18%] vs. 15 [45%], p=.03 and 1 [4%] vs. 10 [30%], p=.008). In chest X-ray at admission, ground-glass opacities (GGOs) and consolidations were more frequent among COVID-19 than influenza patients (19 [68%] and 7 [21%], p<.001). Severe disease and intensive care unit (ICU) admission occurred more often among COVID-19 than influenza patients (26 [93%] vs. 19 [58%], p=.003 and 8 [29%] vs. 2 [6%], p=.034). COVID-19 patients were hospitalized longer than influenza patients (six days [IQR 4-21] vs. 3 [2-4], p<.001).
Conclusions: Bilateral GGOs and consolidations in chest X-ray may help to differentiate COVID-19 from influenza. Hospitalized COVID-19 patients had more severe disease, required longer hospitalization and were admitted to ICU more often than influenza patients, which has important implications for public health policies.
Keywords: COVID-19; adult; characteristics; hospitalized; influenza; outcome.
. 2020 Nov 10;1-11.
doi: 10.1080/23744235.2020.1840623. Online ahead of print.
Comparison of the clinical characteristics and outcomes of hospitalized adult COVID-19 and influenza patients - a prospective observational study
Raija Auvinen[SUP] 1 2 [/SUP], Hanna Nohynek[SUP] 2 [/SUP], Ritva Syrj?nen[SUP] 3 [/SUP], Jukka Ollgren[SUP] 2 [/SUP], Tuija Kerttula[SUP] 4 [/SUP], Jarkko M?ntyl?[SUP] 5 [/SUP], Niina Ikonen[SUP] 6 [/SUP], Raisa Loginov[SUP] 7 [/SUP], Anu Haveri[SUP] 6 [/SUP], Satu Kurkela[SUP] 7 [/SUP], Kirsi Skogberg[SUP] 8 [/SUP]
Affiliations
- PMID: 33170050
- DOI: 10.1080/23744235.2020.1840623
Abstract
Background: We compared the clinical characteristics, findings, and outcomes of hospitalized patients with coronavirus disease 2019 (COVID-19) or influenza to detect relevant differences.
Methods: From December 2019 to April 2020, we recruited all eligible hospitalized adults with respiratory infection to a prospective observational study at a tertiary care hospital in Finland. Influenza and SARS-CoV-2 infections were confirmed by RT-PCR. Follow-up lasted for 3 months from admission.
Results: We included 61 patients, of whom 28 were COVID-19 and 33 influenza patients with median ages of 53 and 56 years. Majority of both COVID-19 and influenza patients were men (61% vs. 67%) and had at least one comorbidity (68% vs. 85%). Pulmonary diseases and current smoking were less common among COVID-19 than influenza patients (5 [18%] vs. 15 [45%], p=.03 and 1 [4%] vs. 10 [30%], p=.008). In chest X-ray at admission, ground-glass opacities (GGOs) and consolidations were more frequent among COVID-19 than influenza patients (19 [68%] and 7 [21%], p<.001). Severe disease and intensive care unit (ICU) admission occurred more often among COVID-19 than influenza patients (26 [93%] vs. 19 [58%], p=.003 and 8 [29%] vs. 2 [6%], p=.034). COVID-19 patients were hospitalized longer than influenza patients (six days [IQR 4-21] vs. 3 [2-4], p<.001).
Conclusions: Bilateral GGOs and consolidations in chest X-ray may help to differentiate COVID-19 from influenza. Hospitalized COVID-19 patients had more severe disease, required longer hospitalization and were admitted to ICU more often than influenza patients, which has important implications for public health policies.
Keywords: COVID-19; adult; characteristics; hospitalized; influenza; outcome.