Infect Genet Evol . Two prolonged viremic SARS-CoV-2 infections with conserved viral genome for two months

[tetano]

Infect Genet Evol


. 2020 Dec 19;104684.
doi: 10.1016/j.meegid.2020.104684. Online ahead of print.
Two prolonged viremic SARS-CoV-2 infections with conserved viral genome for two months


Laith J Abu-Raddad[SUP] 1 [/SUP], Hiam Chemaitelly[SUP] 2 [/SUP], Joel A Malek[SUP] 3 [/SUP], Ayeda A Ahmed[SUP] 4 [/SUP], Yasmin A Mohamoud[SUP] 4 [/SUP], Shameem Younuskunju[SUP] 4 [/SUP], Zaina Al Kanaani[SUP] 5 [/SUP], Abdullatif Al Khal[SUP] 5 [/SUP], Einas Al Kuwari[SUP] 5 [/SUP], Adeel A Butt[SUP] 5 [/SUP], Peter Coyle[SUP] 5 [/SUP], Andrew Jeremijenko[SUP] 5 [/SUP], Anvar Hassan Kaleeckal[SUP] 5 [/SUP], Ali Nizar Latif[SUP] 5 [/SUP], Riyazuddin Mohammad Shaik[SUP] 5 [/SUP], Hanan F Abdul Rahim[SUP] 6 [/SUP], Hadi M Yassine[SUP] 7 [/SUP], Mohamed G Al Kuwari[SUP] 8 [/SUP], Hamad Eid Al Romaihi[SUP] 9 [/SUP], Mohamed H Al-Thani[SUP] 9 [/SUP], Roberto Bertollini[SUP] 9 [/SUP]



Affiliations

• PMID: 33352320
• DOI: 10.1016/j.meegid.2020.104684

Abstract

We document two cases of viremic and prolonged active infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) where the viral genome was conserved for two months, but infection was with little or no symptoms. The first infection persisted for 80 days and the second for 62 days. Clearance of infection occurred 40 and 41 days, respectively, after development of detectable antibodies. Both cases were identified incidentally in an investigation of reinfection in a cohort of 133,266 laboratory-confirmed infected persons.

Keywords: COVID-19; Epidemiology; Genome; Infection; Infectious period; SARS-CoV-2.