tetano
Editor, Senior Moderator
Inflammation
. 2021 Sep 17;1-5.
doi: 10.1007/s10753-021-01563-3. Online ahead of print.
Pericardial Cytokine "Storm" in a COVID-19 Patient: the Confirmation of a Hypothesis
Cristian Deana[SUP] 1 [/SUP], Luigi Vetrugno[SUP] 2 3 [/SUP], Martina Fabris[SUP] 3 4 [/SUP], Francesco Curcio[SUP] 3 4 [/SUP], Emanuela Sozio[SUP] 5 [/SUP], Carlo Tascini[SUP] 3 5 [/SUP], Flavio Bassi[SUP] 2 [/SUP]
Affiliations
Abstract
Novel Coronavirus Disease in most cases produces mild symptoms which resolve after a few days. Some authors hypothesized that SARS-CoV-2 infection could trigger excessive cytokine production leading to a severe multi-organ disease requiring intensive care admission. Respiratory and neurological symptoms are the most frequently reported manifestation of the disease. Indeed, cardiac involvement is reported mostly as a part of a systemic disease. Few isolated cardiac manifestations of COVID-19 infection have been described. We report herein a case of SARS-CoV-2 related severe isolated pericardial involvement requiring ICU admission due to cardiac tamponade needing urgent drainage. Analysis of pericardial fluid from drainage demonstrated a higher cytokine concentration than blood values. Other causes of pericardial disease, such as autoimmunity, bacterial or other than COVID-19 infection, neoplasms or acute myocardial infarction were also evaluated, but all tests confirmed negative results. The suspicion of isolated involvement of the pericardium was therefore demonstrated by the analysis of cytokines which strongly support our hypothesis.
Keywords: COVID-19; cardiac tamponade; cytokines; echocardiography; immunoglobulin test anti SARS–CoV–2; pericardial drainage.
. 2021 Sep 17;1-5.
doi: 10.1007/s10753-021-01563-3. Online ahead of print.
Pericardial Cytokine "Storm" in a COVID-19 Patient: the Confirmation of a Hypothesis
Cristian Deana[SUP] 1 [/SUP], Luigi Vetrugno[SUP] 2 3 [/SUP], Martina Fabris[SUP] 3 4 [/SUP], Francesco Curcio[SUP] 3 4 [/SUP], Emanuela Sozio[SUP] 5 [/SUP], Carlo Tascini[SUP] 3 5 [/SUP], Flavio Bassi[SUP] 2 [/SUP]
Affiliations
- PMID: 34533672
- PMCID: PMC8446479
- DOI: 10.1007/s10753-021-01563-3
Abstract
Novel Coronavirus Disease in most cases produces mild symptoms which resolve after a few days. Some authors hypothesized that SARS-CoV-2 infection could trigger excessive cytokine production leading to a severe multi-organ disease requiring intensive care admission. Respiratory and neurological symptoms are the most frequently reported manifestation of the disease. Indeed, cardiac involvement is reported mostly as a part of a systemic disease. Few isolated cardiac manifestations of COVID-19 infection have been described. We report herein a case of SARS-CoV-2 related severe isolated pericardial involvement requiring ICU admission due to cardiac tamponade needing urgent drainage. Analysis of pericardial fluid from drainage demonstrated a higher cytokine concentration than blood values. Other causes of pericardial disease, such as autoimmunity, bacterial or other than COVID-19 infection, neoplasms or acute myocardial infarction were also evaluated, but all tests confirmed negative results. The suspicion of isolated involvement of the pericardium was therefore demonstrated by the analysis of cytokines which strongly support our hypothesis.
Keywords: COVID-19; cardiac tamponade; cytokines; echocardiography; immunoglobulin test anti SARS–CoV–2; pericardial drainage.