tetano
Editor, Senior Moderator
Virol J. 2013 Apr 23;10(1):128. [Epub ahead of print]
Influenza A virus induced bacterial otitis media is independent of virus tropism for alpha2,6-linked sialic acid.
Short KR, Habets MN, Payne J, Reading PC, Diavatopoulos DA, Wijburg OL.
Abstract
BACKGROUND:
Otitis media (OM) affects >=80% of children before the age of three. OM can arise following co-infection with influenza A virus (IAV) and the bacterium Streptococcus pneumoniae. We have previously shown that H3 IAV strains (such as Udorn/72) induced a higher rate of bacterial OM than H1 strains (such as PR8/34). This was associated with more efficient replication of H3 strains in the middle ear.
FINDINGS:
Here, we assess if the increased replication of IAV strains such as Udorn/72 in the middle ear is dependent upon the binding of the viral HA to alpha2,6-linked sialic acid. Using murine and in vitro models, the present study shows that recognition of alpha2,6-linked sialic acid was not required to facilitate bacterial OM.
CONCLUSIONS:
Taken together, these data suggest that other features of the HA mediate bacterial OM.
PMID:
23617940
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23617940
Influenza A virus induced bacterial otitis media is independent of virus tropism for alpha2,6-linked sialic acid.
Short KR, Habets MN, Payne J, Reading PC, Diavatopoulos DA, Wijburg OL.
Abstract
BACKGROUND:
Otitis media (OM) affects >=80% of children before the age of three. OM can arise following co-infection with influenza A virus (IAV) and the bacterium Streptococcus pneumoniae. We have previously shown that H3 IAV strains (such as Udorn/72) induced a higher rate of bacterial OM than H1 strains (such as PR8/34). This was associated with more efficient replication of H3 strains in the middle ear.
FINDINGS:
Here, we assess if the increased replication of IAV strains such as Udorn/72 in the middle ear is dependent upon the binding of the viral HA to alpha2,6-linked sialic acid. Using murine and in vitro models, the present study shows that recognition of alpha2,6-linked sialic acid was not required to facilitate bacterial OM.
CONCLUSIONS:
Taken together, these data suggest that other features of the HA mediate bacterial OM.
PMID:
23617940
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23617940