tetano
Editor, Senior Moderator
Influenza Other Respir Viruses. 2019 Nov 20. doi: 10.1111/irv.12704. [Epub ahead of print] [h=1]Influenza in patients with cancer after 2009 pandemic AH1N1: An 8-year follow-up study in Mexico.[/h]
?ngeles-Sistac D[SUP]1[/SUP], Martin-Onraet A[SUP]1[/SUP], Cornejo-Ju?rez P[SUP]1[/SUP], Volkow P[SUP]1[/SUP], P?rez-Jimenez C[SUP]1[/SUP], Vilar-Compte D[SUP]1[/SUP].
[h=3]Author information[/h] 1 Department of Infectious Diseases, Instituto Nacional de Cancerolog?a, Mexico City, Mexico.
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Immunosupressed patients are at high risk of influenza-related complications. Influenza AH1N1 has been hypothesized to induce worse outcomes in patients with malignancies, but after the A(H1N1)pdm09 few publications have analyzed the presentation and complications related to influenza afterward.
[h=4]OBJECTIVES:[/h] We aimed to describe the characteristics, risk factors, and outcomes of influenza in an oncologic center after the 2009 pandemic and to compare our case distribution to the National community acquired influenza databases in Mexico and the United States.
[h=4]METHODS:[/h] We reviewed the cases of confirmed influenza in patients with cancer from an oncological center in Mexico from April 2009 to April 2017. Data on severity and influenza type, malignancy, comorbidities, and outcomes were recorded. We correlated data between the Centers for Disease Control and Prevention (CDC) in the United States and SISVEFLU (Influenza Surveillance Program) in Mexico.
[h=4]RESULTS:[/h] One hundred eighty-eight patients were included; 75 (39.9%) had a solid neoplasm and 113 (60.1%) had hematologic malignancies. AH1N1 was the most frequent influenza type (54.2%). Patients with hematologic malignancies had more pneumonia (55% vs 25%, P < .001), needed more hospitalizations (75% vs 39% P < .001), had higher all-cause mortality at 30 days (20% vs 9% P = .048) and influenza-associated mortality (17% vs 7% P = .041). Thirty (16%) patients died within 30 days, and 24 (12.7%) were related to influenza. Influenza type was not associated with worse outcomes. Yearly occurrence of influenza reported by the CDC and SISVEFLU showed a significant correlation (ρ = 0.823, P = .006).
[h=4]CONCLUSIONS:[/h] AH1N1 was the dominant serotype. Patients with hematologic malignancies had more severe influenza and presented worse outcomes. Annual SISVEFLU and CDC surveillance information showed a similar distribution of cases along time but influenza serotypes did not match for all seasons.
? 2019 The Authors. Influenza and Other Respiratory Viruses published by John Wiley & Sons Ltd.
[h=4]KEYWORDS:[/h] AH1N1; cancer; human; influenza; sentinel surveillance
PMID: 31747133 DOI: 10.1111/irv.12704
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?ngeles-Sistac D[SUP]1[/SUP], Martin-Onraet A[SUP]1[/SUP], Cornejo-Ju?rez P[SUP]1[/SUP], Volkow P[SUP]1[/SUP], P?rez-Jimenez C[SUP]1[/SUP], Vilar-Compte D[SUP]1[/SUP].
[h=3]Author information[/h] 1 Department of Infectious Diseases, Instituto Nacional de Cancerolog?a, Mexico City, Mexico.
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Immunosupressed patients are at high risk of influenza-related complications. Influenza AH1N1 has been hypothesized to induce worse outcomes in patients with malignancies, but after the A(H1N1)pdm09 few publications have analyzed the presentation and complications related to influenza afterward.
[h=4]OBJECTIVES:[/h] We aimed to describe the characteristics, risk factors, and outcomes of influenza in an oncologic center after the 2009 pandemic and to compare our case distribution to the National community acquired influenza databases in Mexico and the United States.
[h=4]METHODS:[/h] We reviewed the cases of confirmed influenza in patients with cancer from an oncological center in Mexico from April 2009 to April 2017. Data on severity and influenza type, malignancy, comorbidities, and outcomes were recorded. We correlated data between the Centers for Disease Control and Prevention (CDC) in the United States and SISVEFLU (Influenza Surveillance Program) in Mexico.
[h=4]RESULTS:[/h] One hundred eighty-eight patients were included; 75 (39.9%) had a solid neoplasm and 113 (60.1%) had hematologic malignancies. AH1N1 was the most frequent influenza type (54.2%). Patients with hematologic malignancies had more pneumonia (55% vs 25%, P < .001), needed more hospitalizations (75% vs 39% P < .001), had higher all-cause mortality at 30 days (20% vs 9% P = .048) and influenza-associated mortality (17% vs 7% P = .041). Thirty (16%) patients died within 30 days, and 24 (12.7%) were related to influenza. Influenza type was not associated with worse outcomes. Yearly occurrence of influenza reported by the CDC and SISVEFLU showed a significant correlation (ρ = 0.823, P = .006).
[h=4]CONCLUSIONS:[/h] AH1N1 was the dominant serotype. Patients with hematologic malignancies had more severe influenza and presented worse outcomes. Annual SISVEFLU and CDC surveillance information showed a similar distribution of cases along time but influenza serotypes did not match for all seasons.
? 2019 The Authors. Influenza and Other Respiratory Viruses published by John Wiley & Sons Ltd.
[h=4]KEYWORDS:[/h] AH1N1; cancer; human; influenza; sentinel surveillance
PMID: 31747133 DOI: 10.1111/irv.12704
Free full text