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Influenza Other Respir Viruses . Comparative Effectiveness of Cell-Based Versus Egg-Based Influenza Vaccines in Prevention of Influenza Hospitaliza

tetano

Editor, Senior Moderator
Influenza Other Respir Viruses


. 2024 Dec;18(12):e70025.
doi: 10.1111/irv.70025. Comparative Effectiveness of Cell-Based Versus Egg-Based Influenza Vaccines in Prevention of Influenza Hospitalization During the 2022-2023 Season Among Adults 18-64 Years

Emily Rayens[SUP] 1 [/SUP], Jennifer H Ku[SUP] 1 [/SUP], Lina S Sy[SUP] 1 [/SUP], Lei Qian[SUP] 1 [/SUP], Bradley K Ackerson[SUP] 1 [/SUP], Yi Luo[SUP] 1 [/SUP], Julia E Tubert[SUP] 1 [/SUP], Gina S Lee[SUP] 1 [/SUP], Punam P Modha[SUP] 1 [/SUP], Yoonyoung Park[SUP] 2 [/SUP], Tianyu Sun[SUP] 3 [/SUP], Evan J Anderson[SUP] 2 [/SUP], Hung Fu Tseng[SUP] 1 4 [/SUP]



Affiliations
Abstract

This retrospective cohort study evaluated the comparative vaccine effectiveness (cVE) of licensed standard-dose cell-based versus egg-based influenza vaccines in preventing influenza hospitalization among adults 18-64 years during the 2022-2023 season. The cohort included eligible Kaiser Permanente Southern California members who received ≥ 1 dose of influenza vaccine (n = 848,334). The adjusted cVE against influenza hospitalization was -10.1% (95% CI: -49.8%, 37.8%) in the 18- to 49-year-old cohort. In the 50- to 64-year-old cohort, the adjusted cVE was 14.9% (-33.8%, 52.1%). Cell-based and egg-based influenza vaccines conferred comparable protection against influenza hospitalization in adults 18-64 years of age in the 2022-2023 season.

Keywords: Influenza; epidemiology; influenza vaccine; vaccine effectiveness.

 
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