tetano
Editor, Senior Moderator
Influenza Other Respir Viruses
. 2024 Jan 5;18(1):e13246.
doi: 10.1111/irv.13246. eCollection 2024 Jan. In-field detection and characterization of B/Victoria lineage deletion variant viruses causing early influenza activity and an outbreak in Louisiana, 2019
Bo Shu[SUP] 1 [/SUP], Malania M Wilson[SUP] 1 [/SUP], Matthew W Keller[SUP] 1 [/SUP], Ha Tran[SUP] 2 [/SUP], Theresa Sokol[SUP] 3 [/SUP], Grace Lee[SUP] 3 [/SUP], Benjamin L Rambo-Martin[SUP] 1 [/SUP], Marie K Kirby[SUP] 1 [/SUP], Norman Hassell[SUP] 1 [/SUP], Danielle Haydel[SUP] 2 [/SUP], Julie Hand[SUP] 3 [/SUP], David E Wentworth[SUP] 1 [/SUP], John R Barnes[SUP] 1 [/SUP]
Affiliations
Background: In 2019, the Louisiana Department of Health reported an early influenza B/Victoria (B/VIC) virus outbreak.
Method: As it was an atypically large outbreak, we deployed to Louisiana to investigate it using genomics and a triplex real-time RT-PCR assay to detect three antigenically distinct B/VIC lineage variant viruses.
Results: The investigation indicated that B/VIC V1A.3 subclade, containing a three amino acid deletion in the hemagglutinin and known to be antigenically distinct to the B/Colorado/06/2017 vaccine virus, was the most prevalent circulating virus within the specimens evaluated (86/88 in real-time RT-PCR).
Conclusion: This work underscores the value of portable platforms for rapid, onsite pathogen characterization.
Keywords: B/Victoria lineage; amino acid deletion; influenza outbreak; in‐field detection.
. 2024 Jan 5;18(1):e13246.
doi: 10.1111/irv.13246. eCollection 2024 Jan. In-field detection and characterization of B/Victoria lineage deletion variant viruses causing early influenza activity and an outbreak in Louisiana, 2019
Bo Shu[SUP] 1 [/SUP], Malania M Wilson[SUP] 1 [/SUP], Matthew W Keller[SUP] 1 [/SUP], Ha Tran[SUP] 2 [/SUP], Theresa Sokol[SUP] 3 [/SUP], Grace Lee[SUP] 3 [/SUP], Benjamin L Rambo-Martin[SUP] 1 [/SUP], Marie K Kirby[SUP] 1 [/SUP], Norman Hassell[SUP] 1 [/SUP], Danielle Haydel[SUP] 2 [/SUP], Julie Hand[SUP] 3 [/SUP], David E Wentworth[SUP] 1 [/SUP], John R Barnes[SUP] 1 [/SUP]
Affiliations
- PMID: 38188372
- PMCID: PMC10767671
- DOI: 10.1111/irv.13246
Background: In 2019, the Louisiana Department of Health reported an early influenza B/Victoria (B/VIC) virus outbreak.
Method: As it was an atypically large outbreak, we deployed to Louisiana to investigate it using genomics and a triplex real-time RT-PCR assay to detect three antigenically distinct B/VIC lineage variant viruses.
Results: The investigation indicated that B/VIC V1A.3 subclade, containing a three amino acid deletion in the hemagglutinin and known to be antigenically distinct to the B/Colorado/06/2017 vaccine virus, was the most prevalent circulating virus within the specimens evaluated (86/88 in real-time RT-PCR).
Conclusion: This work underscores the value of portable platforms for rapid, onsite pathogen characterization.
Keywords: B/Victoria lineage; amino acid deletion; influenza outbreak; in‐field detection.