tetano
Editor, Senior Moderator
J Immunol. 2014 Jul 15;193(2):469-475.
Influenza-Specific Antibody-Dependent Cellular Cytotoxicity: Toward a Universal Influenza Vaccine.
Jegaskanda S1, Reading PC2, Kent SJ3.
Author information
Abstract
There is an urgent need for universal influenza vaccines that can control emerging pandemic influenza virus threats without the need to generate new vaccines for each strain. Neutralizing Abs to the influenza virus hemagglutinin glycoprotein are effective at controlling influenza infection but generally target highly variable regions. Abs that can mediate other functions, such as killing influenza-infected cells and activating innate immune responses (termed "Ab-dependent cellular cytotoxicity [ADCC]-mediating Abs"), may assist in protective immunity to influenza. ADCC-mediating Abs can target more conserved regions of influenza virus proteins and recognize a broader array of influenza strains. We review recent research on influenza-specific ADCC Abs and their potential role in improved influenza-vaccination strategies.
Copyright ? 2014 by The American Association of Immunologists, Inc.
PMID:
24994909
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24994909
Influenza-Specific Antibody-Dependent Cellular Cytotoxicity: Toward a Universal Influenza Vaccine.
Jegaskanda S1, Reading PC2, Kent SJ3.
Author information
Abstract
There is an urgent need for universal influenza vaccines that can control emerging pandemic influenza virus threats without the need to generate new vaccines for each strain. Neutralizing Abs to the influenza virus hemagglutinin glycoprotein are effective at controlling influenza infection but generally target highly variable regions. Abs that can mediate other functions, such as killing influenza-infected cells and activating innate immune responses (termed "Ab-dependent cellular cytotoxicity [ADCC]-mediating Abs"), may assist in protective immunity to influenza. ADCC-mediating Abs can target more conserved regions of influenza virus proteins and recognize a broader array of influenza strains. We review recent research on influenza-specific ADCC Abs and their potential role in improved influenza-vaccination strategies.
Copyright ? 2014 by The American Association of Immunologists, Inc.
PMID:
24994909
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24994909