tetano
Editor, Senior Moderator
J Transl Int Med. 2019 Dec 31;7(4):137-142. doi: 10.2478/jtim-2019-0028. eCollection 2019 Dec. [h=1]Influenza Vaccination and Guillain-Barr? Syndrome: Reality or Fear.[/h]
Babazadeh A[SUP]1[/SUP], Mohseni Afshar Z[SUP]2[/SUP], Javanian M[SUP]1[/SUP], Mohammadnia-Afrouzi M[SUP]1[/SUP], Karkhah A[SUP]3[/SUP], Masrour-Roudsari J[SUP]1[/SUP], Sabbagh P[SUP]1[/SUP], Koppolu V[SUP]4[/SUP], Vasigala VK[SUP]5[/SUP], Ebrahimpour S[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Guillain-Barr? syndrome (GBS) is an inflammatory disorder and an acute immune-mediated demyelinating neuropathy that causes reduced signal transmissions, progressive muscle weakness, and paralysis. The etiology of the syndrome still remains controversial and uncertain. GBS can be initiated and triggered by respiratory tract infections such as influenza, and intestinal infections such as Campylobacter jejuni. In addition, there is considerable evidence suggesting links between influenza vaccination and GBS. As reported previously, the incidence of GBS in individuals receiving swine flu vaccine was about one to two cases per million. Despite the influenza vaccine efficacy, its association with an immune-mediated demyelinating process can be challenging as millions of people get vaccinated every year. In this review we will discuss the association between influenza infection and vaccination with GBS by focusing on the possible immunopathological mechanisms.
? 2019 Arefeh Babazadeh et al., published by Sciendo.
[h=4]KEYWORDS:[/h] Guillain–Barr? syndrome; flu vaccination; influenza
PMID: 32010599 PMCID: PMC6985921 DOI: 10.2478/jtim-2019-0028
Free PMC Article
Babazadeh A[SUP]1[/SUP], Mohseni Afshar Z[SUP]2[/SUP], Javanian M[SUP]1[/SUP], Mohammadnia-Afrouzi M[SUP]1[/SUP], Karkhah A[SUP]3[/SUP], Masrour-Roudsari J[SUP]1[/SUP], Sabbagh P[SUP]1[/SUP], Koppolu V[SUP]4[/SUP], Vasigala VK[SUP]5[/SUP], Ebrahimpour S[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Guillain-Barr? syndrome (GBS) is an inflammatory disorder and an acute immune-mediated demyelinating neuropathy that causes reduced signal transmissions, progressive muscle weakness, and paralysis. The etiology of the syndrome still remains controversial and uncertain. GBS can be initiated and triggered by respiratory tract infections such as influenza, and intestinal infections such as Campylobacter jejuni. In addition, there is considerable evidence suggesting links between influenza vaccination and GBS. As reported previously, the incidence of GBS in individuals receiving swine flu vaccine was about one to two cases per million. Despite the influenza vaccine efficacy, its association with an immune-mediated demyelinating process can be challenging as millions of people get vaccinated every year. In this review we will discuss the association between influenza infection and vaccination with GBS by focusing on the possible immunopathological mechanisms.
? 2019 Arefeh Babazadeh et al., published by Sciendo.
[h=4]KEYWORDS:[/h] Guillain–Barr? syndrome; flu vaccination; influenza
PMID: 32010599 PMCID: PMC6985921 DOI: 10.2478/jtim-2019-0028
Free PMC Article