tetano
Editor, Senior Moderator
Front Microbiol. 2017 May 22;8:861. doi: 10.3389/fmicb.2017.00861. eCollection 2017.
[h=1]Influenza Virus and Glycemic Variability in Diabetes: A Killer Combination?[/h] Hulme KD[SUP]1[/SUP], Gallo LA[SUP]1,[/SUP][SUP]2[/SUP], Short KR[SUP]1,[/SUP][SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Following the 2009 H1N1 influenza virus pandemic, numerous studies identified the striking link between diabetes mellitus and influenza disease severity. Typically, influenza virus is a self-limiting infection but in individuals who have a pre-existing chronic illness, such as diabetes mellitus, severe influenza can develop. Here, we discuss the latest clinical and experimental evidence for the role of diabetes in predisposing the host to severe influenza. We explore the possible mechanisms that underlie this synergy and highlight the, as yet, unexplored role that blood glucose oscillations may play in disease development. Diabetes is one of the world's fastest growing chronic diseases and influenza virus represents a constant and pervasive threat to human health. It is therefore imperative that we understand how diabetes increases influenza severity in order to mitigate the burden of future influenza epidemics and pandemics.
[h=4]KEYWORDS:[/h] diabetes; glucose; glycemic oscillations; hyperglycemia; influenza
PMID: 28588558 PMCID: PMC5438975 DOI: 10.3389/fmicb.2017.00861
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[h=1]Influenza Virus and Glycemic Variability in Diabetes: A Killer Combination?[/h] Hulme KD[SUP]1[/SUP], Gallo LA[SUP]1,[/SUP][SUP]2[/SUP], Short KR[SUP]1,[/SUP][SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Following the 2009 H1N1 influenza virus pandemic, numerous studies identified the striking link between diabetes mellitus and influenza disease severity. Typically, influenza virus is a self-limiting infection but in individuals who have a pre-existing chronic illness, such as diabetes mellitus, severe influenza can develop. Here, we discuss the latest clinical and experimental evidence for the role of diabetes in predisposing the host to severe influenza. We explore the possible mechanisms that underlie this synergy and highlight the, as yet, unexplored role that blood glucose oscillations may play in disease development. Diabetes is one of the world's fastest growing chronic diseases and influenza virus represents a constant and pervasive threat to human health. It is therefore imperative that we understand how diabetes increases influenza severity in order to mitigate the burden of future influenza epidemics and pandemics.
[h=4]KEYWORDS:[/h] diabetes; glucose; glycemic oscillations; hyperglycemia; influenza
PMID: 28588558 PMCID: PMC5438975 DOI: 10.3389/fmicb.2017.00861
Free full text