tetano
Editor, Senior Moderator
Int J Cardiovasc Imaging
. 2020 Sep 9.
doi: 10.1007/s10554-020-02010-4. Online ahead of print.
Cardiac imaging phenotype in patients with coronavirus disease 2019 (COVID-19): results of the cocarde study
Olivier Lairez[SUP] 1 2 3 4 5 [/SUP], Virginie Blanchard[SUP] 6 7 8 9 [/SUP], Val?rie Houard[SUP] 6 7 [/SUP], Fanny Vardon-Bounes[SUP] 10 [/SUP], Maeva Lemasle[SUP] 6 7 [/SUP], Eve Cariou[SUP] 6 7 [/SUP], Yoan Lavie-Badie[SUP] 6 7 8 [/SUP], St?phanie Ruiz[SUP] 10 [/SUP], St?phanie Cazalbou[SUP] 6 7 [/SUP], Cl?ment Delmas[SUP] 6 [/SUP], Bernard Georges[SUP] 10 [/SUP], Michel Galinier[SUP] 6 7 9 [/SUP], Didier Carri?[SUP] 6 7 9 [/SUP], Jean-Marie Conil[SUP] 10 [/SUP], Vincent Minville[SUP] 9 10 [/SUP]
Affiliations
Abstract
Biological cardiac injury related to the Severe Acute Respiratory Syndrome Coronavirus-2 infection has been associated with excess mortality. However, its functional impact remains unknown. The aim of our study was to explore the impact of biological cardiac injury on myocardial functions in patients with COVID-19. 31 patients with confirmed COVID-19 (CoV+) and 16 controls (CoV-) were prospectively included in this observational study. Demographic data, laboratory findings, comorbidities, treatments and myocardial function assessed by transthoracic echocardiography were collected and analysed in CoV+ with (TnT+) and without (TnT-) elevation of troponin T levels and compared with CoV-. Among CoV+, 13 (42%) exhibited myocardial injury. CoV+/TnT + patients were older, had lower diastolic arterial pressure and were more likely to have hypertension and chronic renal failure compared with CoV+/TnT-. The control group was comparable except for an absence of biological inflammatory syndrome. Left ventricular ejection fraction and global longitudinal strain were not different among the three groups. There was a trend of decreased myocardial work and increased peak systolic tricuspid annular velocity between the CoV- and CoV + patients, which became significant when comparing CoV- and CoV+/TnT+ (2167 ? 359 vs. 1774 ? 521%/mmHg, P = 0.047 and 14 ? 3 vs. 16 ? 3 cm/s, P = 0.037, respectively). There was a decrease of global work efficiency from CoV- (96 ? 2%) to CoV+/TnT- (94 ? 4%) and then CoV+/TnT+ (93 ? 3%, P = 0.042). In conclusion, biological myocardial injury in COVID 19 has low functional impact on left ventricular systolic function.
Keywords: COVID-19; Myocardial work.; SARS-CoV-2; Speckle tracking echocardiography; Strain.
. 2020 Sep 9.
doi: 10.1007/s10554-020-02010-4. Online ahead of print.
Cardiac imaging phenotype in patients with coronavirus disease 2019 (COVID-19): results of the cocarde study
Olivier Lairez[SUP] 1 2 3 4 5 [/SUP], Virginie Blanchard[SUP] 6 7 8 9 [/SUP], Val?rie Houard[SUP] 6 7 [/SUP], Fanny Vardon-Bounes[SUP] 10 [/SUP], Maeva Lemasle[SUP] 6 7 [/SUP], Eve Cariou[SUP] 6 7 [/SUP], Yoan Lavie-Badie[SUP] 6 7 8 [/SUP], St?phanie Ruiz[SUP] 10 [/SUP], St?phanie Cazalbou[SUP] 6 7 [/SUP], Cl?ment Delmas[SUP] 6 [/SUP], Bernard Georges[SUP] 10 [/SUP], Michel Galinier[SUP] 6 7 9 [/SUP], Didier Carri?[SUP] 6 7 9 [/SUP], Jean-Marie Conil[SUP] 10 [/SUP], Vincent Minville[SUP] 9 10 [/SUP]
Affiliations
- PMID: 32902783
- DOI: 10.1007/s10554-020-02010-4
Abstract
Biological cardiac injury related to the Severe Acute Respiratory Syndrome Coronavirus-2 infection has been associated with excess mortality. However, its functional impact remains unknown. The aim of our study was to explore the impact of biological cardiac injury on myocardial functions in patients with COVID-19. 31 patients with confirmed COVID-19 (CoV+) and 16 controls (CoV-) were prospectively included in this observational study. Demographic data, laboratory findings, comorbidities, treatments and myocardial function assessed by transthoracic echocardiography were collected and analysed in CoV+ with (TnT+) and without (TnT-) elevation of troponin T levels and compared with CoV-. Among CoV+, 13 (42%) exhibited myocardial injury. CoV+/TnT + patients were older, had lower diastolic arterial pressure and were more likely to have hypertension and chronic renal failure compared with CoV+/TnT-. The control group was comparable except for an absence of biological inflammatory syndrome. Left ventricular ejection fraction and global longitudinal strain were not different among the three groups. There was a trend of decreased myocardial work and increased peak systolic tricuspid annular velocity between the CoV- and CoV + patients, which became significant when comparing CoV- and CoV+/TnT+ (2167 ? 359 vs. 1774 ? 521%/mmHg, P = 0.047 and 14 ? 3 vs. 16 ? 3 cm/s, P = 0.037, respectively). There was a decrease of global work efficiency from CoV- (96 ? 2%) to CoV+/TnT- (94 ? 4%) and then CoV+/TnT+ (93 ? 3%, P = 0.042). In conclusion, biological myocardial injury in COVID 19 has low functional impact on left ventricular systolic function.
Keywords: COVID-19; Myocardial work.; SARS-CoV-2; Speckle tracking echocardiography; Strain.